Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition

BACKGROUND: Epidermal growth factor receptor (EGFR) is an essential target for cancer treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic cancer therapy. Here, we showed the underlying mechanism of tumor microenvironment suppressing the sensitivity of EGFR inhi...

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Detalles Bibliográficos
Autores principales: Shi, Xiuhui, Wang, Min, Zhang, Yuqing, Guo, Xingjun, Liu, Mingyang, Zhou, Zhijun, Zhao, Yan, He, Ruizhi, Gao, Yang, Liu, Yuhui, Pan, Shutao, Zhou, Min, Zhao, Chunle, Yin, Taoyuan, Li, Xu, Wang, Hebin, Yang, Jingxuan, Zhu, Feng, Li, Min, Qin, Renyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664470/
https://www.ncbi.nlm.nih.gov/pubmed/36371988
http://dx.doi.org/10.1016/j.ebiom.2022.104352

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