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Bifunctional Skipped Dienes through Cu/Pd-Catalyzed Allylboration of Alkynes with B(2)pin(2) and Vinyl Epoxides
[Image: see text] A method for the use of vinyl epoxides in catalytic allylboration of alkynes is described. This transformation allows for the synthesis of bifunctional skipped dienes bearing both an allylic alcohol and an alkenylboronate from simple starting materials with high regio- and stereose...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664487/ https://www.ncbi.nlm.nih.gov/pubmed/36327136 http://dx.doi.org/10.1021/acs.orglett.2c03390 |
| Sumario: | [Image: see text] A method for the use of vinyl epoxides in catalytic allylboration of alkynes is described. This transformation allows for the synthesis of bifunctional skipped dienes bearing both an allylic alcohol and an alkenylboronate from simple starting materials with high regio- and stereoselectivity. These two functionalities provide these products with highly versatile reactivity, as shown by their stereocontrolled conversion into cyclic boron compounds and polyenes. |
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