Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet quality of life and continuation of therapy can be constrained by immune-related adverse events (irAEs). Limited understanding of irAE mechanisms hampers development of approaches to mitigate their damage. To address this, we...

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Detalles Bibliográficos
Autores principales: Zhou, Yifan, Medik, Yusra B., Patel, Bhakti, Zamler, Daniel B., Chen, Sijie, Chapman, Thomas, Schneider, Sarah, Park, Elizabeth M., Babcock, Rachel L., Chrisikos, Taylor T., Kahn, Laura M., Dyevoich, Allison M., Pineda, Josue E., Wong, Matthew C., Mishra, Aditya K., Cass, Samuel H., Cogdill, Alexandria P., Johnson, Daniel H., Johnson, Sarah B., Wani, Khalida, Ledesma, Debora A., Hudgens, Courtney W., Wang, Jingjing, Wadud Khan, Md Abdul, Peterson, Christine B., Joon, Aron Y., Peng, Weiyi, Li, Haiyan S., Arora, Reetakshi, Tang, Ximing, Raso, Maria Gabriela, Zhang, Xuegong, Foo, Wai Chin, Tetzlaff, Michael T., Diehl, Gretchen E., Clise-Dwyer, Karen, Whitley, Elizabeth M., Gubin, Matthew M., Allison, James P., Hwu, Patrick, Ajami, Nadim J., Diab, Adi, Wargo, Jennifer A., Watowich, Stephanie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664499/
https://www.ncbi.nlm.nih.gov/pubmed/36367776
http://dx.doi.org/10.1084/jem.20221333

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