Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential

HOXA9 functioning as a transcription factor is one of the members of HOX gene family, which governs multiple cellular activities by facilitating cellular signal transduction. In addition to be a driver in AML which has been widely studied, the role of HOXA9 in solid tumor progression has also receiv...

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Autores principales: Tang, Ling, Peng, Lin, Tan, Chao, Liu, Huai, Chen, Pan, Wang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664671/
https://www.ncbi.nlm.nih.gov/pubmed/36376832
http://dx.doi.org/10.1186/s12935-022-02767-9
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author Tang, Ling
Peng, Lin
Tan, Chao
Liu, Huai
Chen, Pan
Wang, Hui
author_facet Tang, Ling
Peng, Lin
Tan, Chao
Liu, Huai
Chen, Pan
Wang, Hui
author_sort Tang, Ling
collection PubMed
description HOXA9 functioning as a transcription factor is one of the members of HOX gene family, which governs multiple cellular activities by facilitating cellular signal transduction. In addition to be a driver in AML which has been widely studied, the role of HOXA9 in solid tumor progression has also received increasing attention in recent years, where the aberrant expression of HOXA9 is closely associated with the prognosis of patient. This review details the signaling pathways, binding partners, post-transcriptional regulation of HOXA9, and possible inhibitors of HOXA9 in solid tumors, which provides a reference basis for further study on the role of HOXA9 in solid tumors.
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spelling pubmed-96646712022-11-15 Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential Tang, Ling Peng, Lin Tan, Chao Liu, Huai Chen, Pan Wang, Hui Cancer Cell Int Review HOXA9 functioning as a transcription factor is one of the members of HOX gene family, which governs multiple cellular activities by facilitating cellular signal transduction. In addition to be a driver in AML which has been widely studied, the role of HOXA9 in solid tumor progression has also received increasing attention in recent years, where the aberrant expression of HOXA9 is closely associated with the prognosis of patient. This review details the signaling pathways, binding partners, post-transcriptional regulation of HOXA9, and possible inhibitors of HOXA9 in solid tumors, which provides a reference basis for further study on the role of HOXA9 in solid tumors. BioMed Central 2022-11-14 /pmc/articles/PMC9664671/ /pubmed/36376832 http://dx.doi.org/10.1186/s12935-022-02767-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Tang, Ling
Peng, Lin
Tan, Chao
Liu, Huai
Chen, Pan
Wang, Hui
Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
title Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
title_full Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
title_fullStr Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
title_full_unstemmed Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
title_short Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential
title_sort role of hoxa9 in solid tumors: mechanistic insights and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664671/
https://www.ncbi.nlm.nih.gov/pubmed/36376832
http://dx.doi.org/10.1186/s12935-022-02767-9
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