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Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke

BACKGROUND: C1q/TNF-related protein 9 (CTRP9) and adiponectin (APN) have beneficial metabolic regulatory and vasoprotective effects. This study explored alteration of CTRP9 and APN multimers during onset of ischemic stroke and development, to provide novel clinical and experimental basis for recogni...

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Autores principales: Zhang, Yan-Qing, Zhang, Yan-Wei, Dai, Jian-Li, Li, Chen, Wang, Wen-Qing, Zhang, Hai-Feng, Lau, Wayne Bond, Wang, Xiao-Ming, Liu, Xiao-Gang, Li, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664773/
https://www.ncbi.nlm.nih.gov/pubmed/36380279
http://dx.doi.org/10.1186/s12883-022-02967-w
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author Zhang, Yan-Qing
Zhang, Yan-Wei
Dai, Jian-Li
Li, Chen
Wang, Wen-Qing
Zhang, Hai-Feng
Lau, Wayne Bond
Wang, Xiao-Ming
Liu, Xiao-Gang
Li, Rong
author_facet Zhang, Yan-Qing
Zhang, Yan-Wei
Dai, Jian-Li
Li, Chen
Wang, Wen-Qing
Zhang, Hai-Feng
Lau, Wayne Bond
Wang, Xiao-Ming
Liu, Xiao-Gang
Li, Rong
author_sort Zhang, Yan-Qing
collection PubMed
description BACKGROUND: C1q/TNF-related protein 9 (CTRP9) and adiponectin (APN) have beneficial metabolic regulatory and vasoprotective effects. This study explored alteration of CTRP9 and APN multimers during onset of ischemic stroke and development, to provide novel clinical and experimental basis for recognition and prevention of ischemic stroke. METHODS: There were 269 patients with ischemic stroke and 182 control subjects included in this study. Serum levels of CTRP9 and APN multimers in different disease stages were measured. RESULTS: Serum CTRP9, total APN (tAPN), and high-molecular weight (HMW) APN decreased gradually in stage I (acute stage, within 72 h of onset) of ischemic stroke and increased during stage III (11th day to one month) and stage IV (1 month after), compared to control. In the non-hyperlipidemia group, serum CTRP9, tAPN, and HMW were decreased in ischemic stroke patients compared to control (P < 0.05). Serum CTRP9 is closely related to serum tAPN and HMW (r = 0.992, 0.991). Serum CTRP9 are protective against ischemic stroke (OR = 0.400, 95% CI 0.197–0.810, P < 0.05). CONCLUSIONS: Lower serum CTRP9, tAPN, LMW, and HMW are significantly associated with increased ischemic stroke risk in non-hyperlipidemia subjects. CTRP9, tAPN, and HMW isoforms may be valuable clinical indicators for patients with ischemic stroke. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-022-02967-w.
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spelling pubmed-96647732022-11-15 Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke Zhang, Yan-Qing Zhang, Yan-Wei Dai, Jian-Li Li, Chen Wang, Wen-Qing Zhang, Hai-Feng Lau, Wayne Bond Wang, Xiao-Ming Liu, Xiao-Gang Li, Rong BMC Neurol Research Article BACKGROUND: C1q/TNF-related protein 9 (CTRP9) and adiponectin (APN) have beneficial metabolic regulatory and vasoprotective effects. This study explored alteration of CTRP9 and APN multimers during onset of ischemic stroke and development, to provide novel clinical and experimental basis for recognition and prevention of ischemic stroke. METHODS: There were 269 patients with ischemic stroke and 182 control subjects included in this study. Serum levels of CTRP9 and APN multimers in different disease stages were measured. RESULTS: Serum CTRP9, total APN (tAPN), and high-molecular weight (HMW) APN decreased gradually in stage I (acute stage, within 72 h of onset) of ischemic stroke and increased during stage III (11th day to one month) and stage IV (1 month after), compared to control. In the non-hyperlipidemia group, serum CTRP9, tAPN, and HMW were decreased in ischemic stroke patients compared to control (P < 0.05). Serum CTRP9 is closely related to serum tAPN and HMW (r = 0.992, 0.991). Serum CTRP9 are protective against ischemic stroke (OR = 0.400, 95% CI 0.197–0.810, P < 0.05). CONCLUSIONS: Lower serum CTRP9, tAPN, LMW, and HMW are significantly associated with increased ischemic stroke risk in non-hyperlipidemia subjects. CTRP9, tAPN, and HMW isoforms may be valuable clinical indicators for patients with ischemic stroke. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-022-02967-w. BioMed Central 2022-11-15 /pmc/articles/PMC9664773/ /pubmed/36380279 http://dx.doi.org/10.1186/s12883-022-02967-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhang, Yan-Qing
Zhang, Yan-Wei
Dai, Jian-Li
Li, Chen
Wang, Wen-Qing
Zhang, Hai-Feng
Lau, Wayne Bond
Wang, Xiao-Ming
Liu, Xiao-Gang
Li, Rong
Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke
title Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke
title_full Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke
title_fullStr Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke
title_full_unstemmed Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke
title_short Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke
title_sort serum ctrp9 and high-molecular weight adiponectin are associated with ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664773/
https://www.ncbi.nlm.nih.gov/pubmed/36380279
http://dx.doi.org/10.1186/s12883-022-02967-w
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