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Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats

Fluoroquinolone use in children is limited due to its potential toxicity and negative effects on skeletal development, but the actual effects/risks of fluoroquinolones on bone growth and the mechanisms behind fluoroquinolone-driven arthropathy remain unknown. Gepotidacin is a novel, bactericidal, fi...

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Detalles Bibliográficos
Autores principales:	Fishman, Cindy, Caverly Rae, Jessica M., Posobiec, Lorraine M., Laffan, Susan B., Lerman, Steven A., Pearson, Neil, Janmohamed, Salim, Dumont, Etienne, Nunn-Floyd, Deatra, Stanislaus, Dinesh J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664842/ https://www.ncbi.nlm.nih.gov/pubmed/36255258 http://dx.doi.org/10.1128/aac.00483-22

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