Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite

New anti-Entamoeba histolytica multistage drugs are needed because only one drug class, nitroimidazoles, is available for treating invasive disease, and it does not effectively eradicate the infective cyst stage. Zinc ditiocarb (ZnDTC), a main metabolite of the FDA-approved drug disulfiram, was rece...

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Detalles Bibliográficos
Autores principales: Sharma, Ishrya, Farr, Laura, Moonah, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664845/
https://www.ncbi.nlm.nih.gov/pubmed/36255253
http://dx.doi.org/10.1128/aac.00832-22
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author Sharma, Ishrya
Farr, Laura
Moonah, Shannon
author_facet Sharma, Ishrya
Farr, Laura
Moonah, Shannon
author_sort Sharma, Ishrya
collection PubMed
description New anti-Entamoeba histolytica multistage drugs are needed because only one drug class, nitroimidazoles, is available for treating invasive disease, and it does not effectively eradicate the infective cyst stage. Zinc ditiocarb (ZnDTC), a main metabolite of the FDA-approved drug disulfiram, was recently shown to be highly effective against the invasive trophozoite stage. In this brief report, we show that ZnDTC is active against cysts, with similar potency to first-line cysticidal drug paromomycin.
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spelling pubmed-96648452022-11-15 Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite Sharma, Ishrya Farr, Laura Moonah, Shannon Antimicrob Agents Chemother Experimental Therapeutics New anti-Entamoeba histolytica multistage drugs are needed because only one drug class, nitroimidazoles, is available for treating invasive disease, and it does not effectively eradicate the infective cyst stage. Zinc ditiocarb (ZnDTC), a main metabolite of the FDA-approved drug disulfiram, was recently shown to be highly effective against the invasive trophozoite stage. In this brief report, we show that ZnDTC is active against cysts, with similar potency to first-line cysticidal drug paromomycin. American Society for Microbiology 2022-10-18 /pmc/articles/PMC9664845/ /pubmed/36255253 http://dx.doi.org/10.1128/aac.00832-22 Text en Copyright © 2022 Sharma et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Experimental Therapeutics
Sharma, Ishrya
Farr, Laura
Moonah, Shannon
Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite
title Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite
title_full Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite
title_fullStr Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite
title_full_unstemmed Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite
title_short Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite
title_sort alcohol abuse drug disulfiram is effective against cyst stages of entamoeba histolytica parasite
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664845/
https://www.ncbi.nlm.nih.gov/pubmed/36255253
http://dx.doi.org/10.1128/aac.00832-22
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AT moonahshannon alcoholabusedrugdisulfiramiseffectiveagainstcyststagesofentamoebahistolyticaparasite

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