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Spatial Characteristics of the Efflux Pump MexB Determine Inhibitor Binding

The multidrug efflux transporters MexB and MexY in Pseudomonas aeruginosa and AcrB in Escherichia coli contribute to these organisms’ multidrug resistance. Efflux pump inhibitor (EPI) ABI-PP inhibits MexB and AcrB, but not MexY. We previously determined the structure of ABI-PP bound to the hydrophob...

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Detalles Bibliográficos
Autores principales:	Yamasaki, Seiji, Koga, Naoki, Zwama, Martijn, Sakurai, Keisuke, Nakashima, Ryosuke, Yamaguchi, Akihito, Nishino, Kunihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664856/ https://www.ncbi.nlm.nih.gov/pubmed/36300935 http://dx.doi.org/10.1128/aac.00672-22

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