Cargando…

Spatial Characteristics of the Efflux Pump MexB Determine Inhibitor Binding

The multidrug efflux transporters MexB and MexY in Pseudomonas aeruginosa and AcrB in Escherichia coli contribute to these organisms’ multidrug resistance. Efflux pump inhibitor (EPI) ABI-PP inhibits MexB and AcrB, but not MexY. We previously determined the structure of ABI-PP bound to the hydrophob...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamasaki, Seiji, Koga, Naoki, Zwama, Martijn, Sakurai, Keisuke, Nakashima, Ryosuke, Yamaguchi, Akihito, Nishino, Kunihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664856/ https://www.ncbi.nlm.nih.gov/pubmed/36300935 http://dx.doi.org/10.1128/aac.00672-22

Ejemplares similares

Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds
por: Sakurai, Keisuke, et al.
Publicado: (2019)

Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles
por: Zwama, Martijn, et al.
Publicado: (2022)

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
por: Zwama, Martijn, et al.
Publicado: (2018)

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
por: Nishino, Kunihiko, et al.
Publicado: (2021)

Expression of the MexXY Aminoglycoside Efflux Pump and Presence of an Aminoglycoside-Modifying Enzyme in Clinical Pseudomonas aeruginosa Isolates Are Highly Correlated
por: Seupt, Alexander, et al.
Publicado: (2020)

siRNA-mediated gene silencing of MexB from the MexA-MexB-OprM efflux pump in Pseudomonas aeruginosa
por: Gong, Feng-Yun, et al.
Publicado: (2014)

Molecular determinants of avoidance and inhibition of Pseudomonas aeruginosa MexB efflux pump
por: Gervasoni, Silvia, et al.
Publicado: (2023)

Phylogenetic and functional characterisation of the Haemophilus influenzae multidrug efflux pump AcrB
por: Zwama, Martijn, et al.
Publicado: (2019)

Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility
por: Liston, Sean D., et al.
Publicado: (2020)

Identification and Characterization of a Novel Major Facilitator Superfamily Efflux Pump, SA09310, Mediating Tetracycline Resistance in Staphylococcus aureus
por: Li, Daiyu, et al.
Publicado: (2023)

Bifunctional Enzyme SpoT Is Involved in Biofilm Formation of Helicobacter pylori with Multidrug Resistance by Upregulating Efflux Pump Hp1174 (gluP)
por: Ge, Xiaoran, et al.
Publicado: (2018)

Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosa
por: Yamasaki, Seiji, et al.
Publicado: (2023)

Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of Pseudomonas aeruginosa
por: Gervasoni, Silvia, et al.
Publicado: (2022)

Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition
por: Niimi, Masakazu, et al.
Publicado: (2022)

Characterization of Proteobacterial Plasmid Integron-Encoded qac Efflux Pump Sequence Diversity and Quaternary Ammonium Compound Antiseptic Selection in Escherichia coli Grown Planktonically and as Biofilms
por: Slipski, Carmine J., et al.
Publicado: (2021)

The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis
por: Hürlimann, Lea M., et al.
Publicado: (2016)

Functional Role of YnfA, an Efflux Transporter in Resistance to Antimicrobial Agents in Shigella flexneri
por: Sen, Tanuka, et al.
Publicado: (2022)

Pyrogallol and Fluconazole Interact Synergistically In Vitro against Candida glabrata through an Efflux-Associated Mechanism
por: Yao, Dongting, et al.
Publicado: (2021)

Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time
por: Zwama, Martijn, et al.
Publicado: (2021)

Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
por: Glavier, Marie, et al.
Publicado: (2020)

Catch me if you can: a biotinylated proteoliposome affinity assay for the investigation of assembly of the MexA-MexB-OprM efflux pump from Pseudomonas aeruginosa
por: Ntsogo Enguéné, Véronique Yvette, et al.
Publicado: (2015)

Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains
por: Zwama, Martijn, et al.
Publicado: (2017)

Molecular Determinants of the Promiscuity of MexB and MexY Multidrug Transporters of Pseudomonas aeruginosa
por: Ramaswamy, Venkata K., et al.
Publicado: (2018)

Genome-Wide Transposon Screen of a Pseudomonas syringae mexB Mutant Reveals the Substrates of Efflux Transporters
por: Helmann, Tyler C., et al.
Publicado: (2019)

Alliance of Efflux Pumps with β-Lactamases in Multidrug-Resistant Klebsiella pneumoniae Isolates
por: Maurya, Navdezda, et al.
Publicado: (2019)

Identification of Genetic Variants via Bacterial Respiration Gas Analysis
por: Koga, Naoki, et al.
Publicado: (2020)

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA
por: Gould, Matthew K., et al.
Publicado: (2013)

Mutagenesis Mapping of the Protein-Protein Interaction Underlying FusB-Type Fusidic Acid Resistance
por: Cox, Georgina, et al.
Publicado: (2013)

A Novel Gene Amplification Causes Upregulation of the PatAB ABC Transporter and Fluoroquinolone Resistance in Streptococcus pneumoniae
por: Baylay, Alison J., et al.
Publicado: (2015)

The Mu Subunit of Plasmodium falciparum Clathrin-Associated Adaptor Protein 2 Modulates In Vitro Parasite Response to Artemisinin and Quinine
por: Henriques, Gisela, et al.
Publicado: (2015)

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles
por: Makena, Anne, et al.
Publicado: (2016)

β-Lactamase Characterization of Gram-Negative Pathogens Recovered from Patients Enrolled in the Phase 2 Trials for Ceftazidime-Avibactam: Clinical Efficacies Analyzed against Subsets of Molecularly Characterized Isolates
por: Mendes, Rodrigo E., et al.
Publicado: (2016)

Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates
por: Karah, Nabil, et al.
Publicado: (2016)

First Report of cfr-Carrying Plasmids in the Pandemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Staphylococcal Cassette Chromosome mec Type IV Clone
por: Shore, Anna C., et al.
Publicado: (2016)

Identification of EnvC and Its Cognate Amidases as Novel Determinants of Intrinsic Resistance to Cationic Antimicrobial Peptides
por: Oguri, Tamiko, et al.
Publicado: (2016)

Rapid Emergence and Evolution of Staphylococcus aureus Clones Harboring fusC-Containing Staphylococcal Cassette Chromosome Elements
por: Baines, Sarah L., et al.
Publicado: (2016)

Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance
por: Linkevicius, Marius, et al.
Publicado: (2016)

The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
por: Ochola-Oyier, Lynette Isabella, et al.
Publicado: (2015)

Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae at a Single Institution: Insights into Endemicity from Whole-Genome Sequencing
por: Mathers, Amy J., et al.
Publicado: (2015)

Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies
por: Walker, Louise A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_op8c6iiulvcb5k5lg08q5sobsa