Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library

Malaria is a mosquito-borne fatal infectious disease that affects humans and is caused by Plasmodium parasites, primarily Plasmodium falciparum. Widespread drug resistance compels us to discover novel compounds and alternative drug discovery targets. The coenzyme A (CoA) biosynthesis pathway is esse...

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Detalles Bibliográficos
Autores principales: Nurkanto, Arif, Imamura, Riyo, Rahmawati, Yulia, Prabandari, Erwahyuni Endang, Waluyo, Danang, Annoura, Takeshi, Yamamoto, Kazuki, Sekijima, Masakazu, Nishimura, Yuki, Okabe, Takayoshi, Shiba, Tomoo, Shibata, Norio, Kojima, Hirotatsu, Duffy, James, Nozaki, Tomoyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664868/
https://www.ncbi.nlm.nih.gov/pubmed/36314787
http://dx.doi.org/10.1128/aac.00420-22

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