Multisystemic Inflammatory Syndrome in Children: a step towards a better understanding of this entity

ABSTRACT: As pediatricians, we all have to deal with new childhood inflammatory disorder due to COVID 19: the Multisystem Inflammatory Syndrome in Children (MIS-C). The recent article by Savorgnan et al. on the physiologic profiles associated with MIS-C proposed a classification through the “MIS-C severity score” (MSS). The authors also identified a combination of seven variables collected during the first 3 h of admission in the PICU that contributes to stratify MIS-C severity with an area under the receiver operating characteristic curve (AUC) >0.90. This work represents an important first step in the development of a MIS-C severity score and is a call for collaborative groups to validate the prediction model through multicenter studies and thereby refine the management of MIS-C. IMPACT: The recent article by Savorgnan et al. on physiologic profile associated with MIS-C represents an important first step in the development of an MIS-C severity score and is a call for collaborative groups to validate the prediction model through multicenter studies and thereby refine the management of MIS-C. Our manuscript helps in the methodology interpretation of the manuscript by Savorgnan et al. And our manuscript promotes collaborative work on MIS-C.