Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in...

Descripción completa

Detalles Bibliográficos
Autores principales: Castoldi, Francesca, Kroemer, Guido, Pietrocola, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665084/
https://www.ncbi.nlm.nih.gov/pubmed/36387057
http://dx.doi.org/10.1080/2162402X.2022.2146855
Descripción
Sumario:Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

Ejemplares similares