Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in...

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Detalles Bibliográficos
Autores principales: Castoldi, Francesca, Kroemer, Guido, Pietrocola, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665084/
https://www.ncbi.nlm.nih.gov/pubmed/36387057
http://dx.doi.org/10.1080/2162402X.2022.2146855
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author Castoldi, Francesca
Kroemer, Guido
Pietrocola, Federico
author_facet Castoldi, Francesca
Kroemer, Guido
Pietrocola, Federico
author_sort Castoldi, Francesca
collection PubMed
description Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.
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spelling pubmed-96650842022-11-15 Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice Castoldi, Francesca Kroemer, Guido Pietrocola, Federico Oncoimmunology Commentary Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients. Taylor & Francis 2022-11-14 /pmc/articles/PMC9665084/ /pubmed/36387057 http://dx.doi.org/10.1080/2162402X.2022.2146855 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Castoldi, Francesca
Kroemer, Guido
Pietrocola, Federico
Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
title Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
title_full Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
title_fullStr Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
title_full_unstemmed Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
title_short Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
title_sort spermidine rejuvenates t lymphocytes and restores anticancer immunosurveillance in aged mice
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665084/
https://www.ncbi.nlm.nih.gov/pubmed/36387057
http://dx.doi.org/10.1080/2162402X.2022.2146855
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