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Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665084/ https://www.ncbi.nlm.nih.gov/pubmed/36387057 http://dx.doi.org/10.1080/2162402X.2022.2146855 |