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Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood. We investigate the accuracy of GA clocks and determinants of epigenetic GA acceleration (GAA), a biomarker of biologica...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665122/ https://www.ncbi.nlm.nih.gov/pubmed/35912433 http://dx.doi.org/10.1080/15592294.2022.2102846 |
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author | Daredia, Saher Huen, Karen Van Der Laan, Lars Collender, Philip A. Nwanaji-Enwerem, Jamaji C. Harley, Kim Deardorff, Julianna Eskenazi, Brenda Holland, Nina Cardenas, Andres |
author_facet | Daredia, Saher Huen, Karen Van Der Laan, Lars Collender, Philip A. Nwanaji-Enwerem, Jamaji C. Harley, Kim Deardorff, Julianna Eskenazi, Brenda Holland, Nina Cardenas, Andres |
author_sort | Daredia, Saher |
collection | PubMed |
description | Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood. We investigate the accuracy of GA clocks and determinants of epigenetic GA acceleration (GAA), a biomarker of biological ageing. We hypothesize that prenatal and birth characteristics are associated with altered GAA, thereby disrupting foetal biological ageing. We examined 372 mother-child pairs from the Center for the Health Assessment of Mothers and Children of Salinas study of primarily Latino farmworkers in California. Chronological GA was robustly correlated with epigenetic GA (DNAm GA) estimated by the Knight (r = 0.48, p < 2.2x10(−16)) and Bohlin clocks (r = 0.67, p < 2.2x10(−16)) using the Illumina 450K array in cord blood samples collected at birth. GA clock performance was robust, though slightly lower, using DNAm profiles from the Illumina EPIC array in a smaller subsample (Knight: r = 0.39, p < 3.5x10(−5); Bohlin: r = 0.60, p < 7.7x10(−12)). After adjusting for confounders, high maternal serum triglyceride levels (Bohlin: β = −0.01 days per mg/dL, p = 0.03), high maternal serum lipid levels (Bohlin: β = −4.31x10(−3) days per mg/dL, p = 0.04), preterm delivery (Bohlin: β = −4.03 days, p = 9.64x10(−4)), greater maternal parity (Knight: β = −4.07 days, p = 0.01; Bohlin: β = −2.43 days, p = 0.01), and male infant sex (Knight: β = −3.15 days, p = 3.10x10(−3)) were associated with decreased GAA.Prenatal and birth characteristics affect GAA in newborns. Understanding factors that accelerate or delay biological ageing at birth may identify early-life targets for disease prevention and improve ageing across the life-course. Future research should test the impact of altered GAA on the long-term burden of age-related diseases. |
format | Online Article Text |
id | pubmed-9665122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-96651222022-11-15 Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort Daredia, Saher Huen, Karen Van Der Laan, Lars Collender, Philip A. Nwanaji-Enwerem, Jamaji C. Harley, Kim Deardorff, Julianna Eskenazi, Brenda Holland, Nina Cardenas, Andres Epigenetics Research Paper Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood. We investigate the accuracy of GA clocks and determinants of epigenetic GA acceleration (GAA), a biomarker of biological ageing. We hypothesize that prenatal and birth characteristics are associated with altered GAA, thereby disrupting foetal biological ageing. We examined 372 mother-child pairs from the Center for the Health Assessment of Mothers and Children of Salinas study of primarily Latino farmworkers in California. Chronological GA was robustly correlated with epigenetic GA (DNAm GA) estimated by the Knight (r = 0.48, p < 2.2x10(−16)) and Bohlin clocks (r = 0.67, p < 2.2x10(−16)) using the Illumina 450K array in cord blood samples collected at birth. GA clock performance was robust, though slightly lower, using DNAm profiles from the Illumina EPIC array in a smaller subsample (Knight: r = 0.39, p < 3.5x10(−5); Bohlin: r = 0.60, p < 7.7x10(−12)). After adjusting for confounders, high maternal serum triglyceride levels (Bohlin: β = −0.01 days per mg/dL, p = 0.03), high maternal serum lipid levels (Bohlin: β = −4.31x10(−3) days per mg/dL, p = 0.04), preterm delivery (Bohlin: β = −4.03 days, p = 9.64x10(−4)), greater maternal parity (Knight: β = −4.07 days, p = 0.01; Bohlin: β = −2.43 days, p = 0.01), and male infant sex (Knight: β = −3.15 days, p = 3.10x10(−3)) were associated with decreased GAA.Prenatal and birth characteristics affect GAA in newborns. Understanding factors that accelerate or delay biological ageing at birth may identify early-life targets for disease prevention and improve ageing across the life-course. Future research should test the impact of altered GAA on the long-term burden of age-related diseases. Taylor & Francis 2022-08-01 /pmc/articles/PMC9665122/ /pubmed/35912433 http://dx.doi.org/10.1080/15592294.2022.2102846 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Research Paper Daredia, Saher Huen, Karen Van Der Laan, Lars Collender, Philip A. Nwanaji-Enwerem, Jamaji C. Harley, Kim Deardorff, Julianna Eskenazi, Brenda Holland, Nina Cardenas, Andres Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort |
title | Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort |
title_full | Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort |
title_fullStr | Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort |
title_full_unstemmed | Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort |
title_short | Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort |
title_sort | prenatal and birth associations of epigenetic gestational age acceleration in the center for the health assessment of mothers and children of salinas (chamacos) cohort |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665122/ https://www.ncbi.nlm.nih.gov/pubmed/35912433 http://dx.doi.org/10.1080/15592294.2022.2102846 |
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