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Precise epigenomic editing with a SunTag-based modular epigenetic toolkit

Epigenetic regulation is a crucial factor controlling gene expression. Here, we report our CRISPR/dCas9-based modular epigenetic toolkit that enables gene-specific modulation of epigenetic architecture. By modifying the SunTag framework of dCas9 tagged with five GCN4 moieties, each epigenetic writer...

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Detalles Bibliográficos
Autores principales:	Guhathakurta, Subhrangshu, Adams, Levi, Jeong, Inhye, Sivakumar, Anishaa, Cha, Mingyu, Bernardo Fiadeiro, Mariana, Hu, Haiyan Nancy, Kim, Yoon-Seong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665145/ https://www.ncbi.nlm.nih.gov/pubmed/35920441 http://dx.doi.org/10.1080/15592294.2022.2106646

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