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MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy

Intracerebral hemorrhage (ICH) is the most common subtype of hemorrhagic stroke. After ICH, blood components extravasate from vessels into the brain, activating immune cells and causing them to release a series of inflammatory mediators. Immune cells, together with inflammatory mediators, lead to ne...

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Autores principales: Xia, Siqi, Zheng, Yonghe, Yan, Feng, Chen, Gao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665326/
https://www.ncbi.nlm.nih.gov/pubmed/36389834
http://dx.doi.org/10.3389/fimmu.2022.945860
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author Xia, Siqi
Zheng, Yonghe
Yan, Feng
Chen, Gao
author_facet Xia, Siqi
Zheng, Yonghe
Yan, Feng
Chen, Gao
author_sort Xia, Siqi
collection PubMed
description Intracerebral hemorrhage (ICH) is the most common subtype of hemorrhagic stroke. After ICH, blood components extravasate from vessels into the brain, activating immune cells and causing them to release a series of inflammatory mediators. Immune cells, together with inflammatory mediators, lead to neuroinflammation in the perihematomal region and the whole brain, and neuroinflammation is closely related to secondary brain injury as well as functional recovery of the brain. Despite recent progress in understanding the pathophysiology of ICH, there is still no effective treatment for this disease. MicroRNAs (miRNAs) are non-coding RNAs 17–25 nucleotides in length that are generated naturally in the human body. They bind complementarily to messenger RNAs and suppress translation, thus regulating gene expression at the post-transcriptional level. They have been found to regulate the pathophysiological process of ICH, particularly the neuroinflammatory cascade. Multiple preclinical studies have shown that manipulating the expression and activity of miRNAs can modulate immune cell activities, influence neuroinflammatory responses, and ultimately affect neurological functions after ICH. This implicates the potentially crucial roles of miRNAs in post-ICH neuroinflammation and indicates the possibility of applying miRNA-based therapeutics for this disease. Thus, this review aims to address the pathophysiological roles and molecular underpinnings of miRNAs in the regulation of neuroinflammation after ICH. With a more sophisticated understanding of ICH and miRNAs, it is possible to translate these findings into new pharmacological therapies for ICH.
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spelling pubmed-96653262022-11-15 MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy Xia, Siqi Zheng, Yonghe Yan, Feng Chen, Gao Front Immunol Immunology Intracerebral hemorrhage (ICH) is the most common subtype of hemorrhagic stroke. After ICH, blood components extravasate from vessels into the brain, activating immune cells and causing them to release a series of inflammatory mediators. Immune cells, together with inflammatory mediators, lead to neuroinflammation in the perihematomal region and the whole brain, and neuroinflammation is closely related to secondary brain injury as well as functional recovery of the brain. Despite recent progress in understanding the pathophysiology of ICH, there is still no effective treatment for this disease. MicroRNAs (miRNAs) are non-coding RNAs 17–25 nucleotides in length that are generated naturally in the human body. They bind complementarily to messenger RNAs and suppress translation, thus regulating gene expression at the post-transcriptional level. They have been found to regulate the pathophysiological process of ICH, particularly the neuroinflammatory cascade. Multiple preclinical studies have shown that manipulating the expression and activity of miRNAs can modulate immune cell activities, influence neuroinflammatory responses, and ultimately affect neurological functions after ICH. This implicates the potentially crucial roles of miRNAs in post-ICH neuroinflammation and indicates the possibility of applying miRNA-based therapeutics for this disease. Thus, this review aims to address the pathophysiological roles and molecular underpinnings of miRNAs in the regulation of neuroinflammation after ICH. With a more sophisticated understanding of ICH and miRNAs, it is possible to translate these findings into new pharmacological therapies for ICH. Frontiers Media S.A. 2022-11-01 /pmc/articles/PMC9665326/ /pubmed/36389834 http://dx.doi.org/10.3389/fimmu.2022.945860 Text en Copyright © 2022 Xia, Zheng, Yan and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xia, Siqi
Zheng, Yonghe
Yan, Feng
Chen, Gao
MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy
title MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy
title_full MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy
title_fullStr MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy
title_full_unstemmed MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy
title_short MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy
title_sort micrornas modulate neuroinflammation after intracerebral hemorrhage: prospects for new therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665326/
https://www.ncbi.nlm.nih.gov/pubmed/36389834
http://dx.doi.org/10.3389/fimmu.2022.945860
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