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Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife

Purpose  Incidence of early onset neurocognitive dysfunction has been reported in World Trade Center (WTC) responders. Ongoing studies are investigating the underlying etiology, as we are concerned that an underlying risk of neurodegenerative dementia may be occurring because of their stressful and...

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Autores principales: Kritikos, Minos, Franceschi, Ana M., Vaska, Paul, Clouston, Sean A. P., Huang, Chuan, Salerno, Michael, Deri, Yael, Tang, Cheuk, Pellecchia, Alison, Santiago-Michels, Stephanie, Sano, Mary, Bromet, Evelyn J., Lucchini, Roberto G., Gandy, Sam, Luft, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666002/
https://www.ncbi.nlm.nih.gov/pubmed/36398306
http://dx.doi.org/10.1055/s-0042-1750013
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author Kritikos, Minos
Franceschi, Ana M.
Vaska, Paul
Clouston, Sean A. P.
Huang, Chuan
Salerno, Michael
Deri, Yael
Tang, Cheuk
Pellecchia, Alison
Santiago-Michels, Stephanie
Sano, Mary
Bromet, Evelyn J.
Lucchini, Roberto G.
Gandy, Sam
Luft, Benjamin J.
author_facet Kritikos, Minos
Franceschi, Ana M.
Vaska, Paul
Clouston, Sean A. P.
Huang, Chuan
Salerno, Michael
Deri, Yael
Tang, Cheuk
Pellecchia, Alison
Santiago-Michels, Stephanie
Sano, Mary
Bromet, Evelyn J.
Lucchini, Roberto G.
Gandy, Sam
Luft, Benjamin J.
author_sort Kritikos, Minos
collection PubMed
description Purpose  Incidence of early onset neurocognitive dysfunction has been reported in World Trade Center (WTC) responders. Ongoing studies are investigating the underlying etiology, as we are concerned that an underlying risk of neurodegenerative dementia may be occurring because of their stressful and neurotoxic exposures to particulate matter when they responded to the search and rescue efforts on September 11, 2001. The purpose of this study is to report preliminary results from two ongoing positron emission tomography (PET)/magnetic resonance imaging (MRI) imaging studies investigating the presence of Alzheimer's disease (AD) biomarkers, such as β-amyloid, tau, and neurodegeneration, and compare our findings to published norms. Methods  We present findings on 12 WTC responders diagnosed with either cognitive impairment (CI) or mild cognitive impairment (MCI), now at midlife, who underwent PET/MRI brain imaging as part of ongoing studies. Six responders with CI received [ (18) F] florbetaben (FBB) to detect β-amyloidosis and six separate responders with MCI received [ (18) F] flortaucipir (FTP) to detect tauopathy. All 12 responders underwent concomitant MRI scans for gray matter volume analysis of neurodegeneration. Results  PET analysis revealed 50% FBB and 50% of FTP scans were clinically read as positive and that 50% of FTP scans identified as consistent with Braak's stage I or II. Furthermore, one responder identified as centiloid positive for AD. Gray matter volumes from MRI analyses were compared with age/sex-matched norms (Neuroquant), identifying abnormally low cortical volumes in the occipital and temporal lobes, as well as the inferior temporal gyri and the entorhinal cortex. Conclusion  These preliminary results suggest that WTC responders with neurocognitive dysfunction may be at increased risk for a neurodegenerative dementia process as a result of their exposures at September 11, 2001.
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spelling pubmed-96660022022-11-16 Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife Kritikos, Minos Franceschi, Ana M. Vaska, Paul Clouston, Sean A. P. Huang, Chuan Salerno, Michael Deri, Yael Tang, Cheuk Pellecchia, Alison Santiago-Michels, Stephanie Sano, Mary Bromet, Evelyn J. Lucchini, Roberto G. Gandy, Sam Luft, Benjamin J. World J Nucl Med Purpose  Incidence of early onset neurocognitive dysfunction has been reported in World Trade Center (WTC) responders. Ongoing studies are investigating the underlying etiology, as we are concerned that an underlying risk of neurodegenerative dementia may be occurring because of their stressful and neurotoxic exposures to particulate matter when they responded to the search and rescue efforts on September 11, 2001. The purpose of this study is to report preliminary results from two ongoing positron emission tomography (PET)/magnetic resonance imaging (MRI) imaging studies investigating the presence of Alzheimer's disease (AD) biomarkers, such as β-amyloid, tau, and neurodegeneration, and compare our findings to published norms. Methods  We present findings on 12 WTC responders diagnosed with either cognitive impairment (CI) or mild cognitive impairment (MCI), now at midlife, who underwent PET/MRI brain imaging as part of ongoing studies. Six responders with CI received [ (18) F] florbetaben (FBB) to detect β-amyloidosis and six separate responders with MCI received [ (18) F] flortaucipir (FTP) to detect tauopathy. All 12 responders underwent concomitant MRI scans for gray matter volume analysis of neurodegeneration. Results  PET analysis revealed 50% FBB and 50% of FTP scans were clinically read as positive and that 50% of FTP scans identified as consistent with Braak's stage I or II. Furthermore, one responder identified as centiloid positive for AD. Gray matter volumes from MRI analyses were compared with age/sex-matched norms (Neuroquant), identifying abnormally low cortical volumes in the occipital and temporal lobes, as well as the inferior temporal gyri and the entorhinal cortex. Conclusion  These preliminary results suggest that WTC responders with neurocognitive dysfunction may be at increased risk for a neurodegenerative dementia process as a result of their exposures at September 11, 2001. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-09-02 /pmc/articles/PMC9666002/ /pubmed/36398306 http://dx.doi.org/10.1055/s-0042-1750013 Text en World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Kritikos, Minos
Franceschi, Ana M.
Vaska, Paul
Clouston, Sean A. P.
Huang, Chuan
Salerno, Michael
Deri, Yael
Tang, Cheuk
Pellecchia, Alison
Santiago-Michels, Stephanie
Sano, Mary
Bromet, Evelyn J.
Lucchini, Roberto G.
Gandy, Sam
Luft, Benjamin J.
Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife
title Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife
title_full Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife
title_fullStr Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife
title_full_unstemmed Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife
title_short Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife
title_sort assessment of alzheimer's disease imaging biomarkers in world trade center responders with cognitive impairment at midlife
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666002/
https://www.ncbi.nlm.nih.gov/pubmed/36398306
http://dx.doi.org/10.1055/s-0042-1750013
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