Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment

Non-Hodgkin's lymphoma (NHL) with secondary bone marrow involvement is relatively common. However, isolated involvement of bone marrow in marginal zone type of NHL is atypical and rare. Here, we describe a patient of atypical marginal zone lymphoma with isolated bone marrow involvement who pres...

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Autores principales: Gauthaman, Dinesh Kumar, Subramanyam, Padma, Palaniswamy, Shanmuga Sundaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666005/
https://www.ncbi.nlm.nih.gov/pubmed/36398307
http://dx.doi.org/10.1055/s-0042-1750395
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author Gauthaman, Dinesh Kumar
Subramanyam, Padma
Palaniswamy, Shanmuga Sundaram
author_facet Gauthaman, Dinesh Kumar
Subramanyam, Padma
Palaniswamy, Shanmuga Sundaram
author_sort Gauthaman, Dinesh Kumar
collection PubMed
description Non-Hodgkin's lymphoma (NHL) with secondary bone marrow involvement is relatively common. However, isolated involvement of bone marrow in marginal zone type of NHL is atypical and rare. Here, we describe a patient of atypical marginal zone lymphoma with isolated bone marrow involvement who presented with weight loss and bicytopenia, where F-18 FDG PET/CT (fluorine-18-labeled fluorodeoxyglucose positron emission tomography with computed tomography) imaging played a pivotal role in establishing the diagnosis when conventional imaging modalities were unremarkable. The patient was successfully treated with systemic chemotherapy (rituximab, cyclophosphamide, prednisolone) and achieved complete remission, as demonstrated by a follow-up F-18 FDG PET/CT scan.
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spelling pubmed-96660052022-11-16 Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment Gauthaman, Dinesh Kumar Subramanyam, Padma Palaniswamy, Shanmuga Sundaram World J Nucl Med Non-Hodgkin's lymphoma (NHL) with secondary bone marrow involvement is relatively common. However, isolated involvement of bone marrow in marginal zone type of NHL is atypical and rare. Here, we describe a patient of atypical marginal zone lymphoma with isolated bone marrow involvement who presented with weight loss and bicytopenia, where F-18 FDG PET/CT (fluorine-18-labeled fluorodeoxyglucose positron emission tomography with computed tomography) imaging played a pivotal role in establishing the diagnosis when conventional imaging modalities were unremarkable. The patient was successfully treated with systemic chemotherapy (rituximab, cyclophosphamide, prednisolone) and achieved complete remission, as demonstrated by a follow-up F-18 FDG PET/CT scan. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-09-05 /pmc/articles/PMC9666005/ /pubmed/36398307 http://dx.doi.org/10.1055/s-0042-1750395 Text en World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Gauthaman, Dinesh Kumar
Subramanyam, Padma
Palaniswamy, Shanmuga Sundaram
Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment
title Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment
title_full Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment
title_fullStr Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment
title_full_unstemmed Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment
title_short Atypical Presentation of Marginal Zone Lymphoma as Isolated Diffuse Bone Marrow Involvement: Utility of F-18 FDG PET/CT in Diagnosis and Response Assessment
title_sort atypical presentation of marginal zone lymphoma as isolated diffuse bone marrow involvement: utility of f-18 fdg pet/ct in diagnosis and response assessment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666005/
https://www.ncbi.nlm.nih.gov/pubmed/36398307
http://dx.doi.org/10.1055/s-0042-1750395
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AT palaniswamyshanmugasundaram atypicalpresentationofmarginalzonelymphomaasisolateddiffusebonemarrowinvolvementutilityoff18fdgpetctindiagnosisandresponseassessment

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