Cargando…

Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate

Bladder cancer tends to recur, making treatment one of the most expensive in oncology. The limited efficacy and high cost of adjuvant therapies in the treatment of bladder cancer prompt research on new drugs which could replace them. In vitro studies have established that antibiotics can have a cyto...

Descripción completa

Detalles Bibliográficos
Autores principales: Kowalski, Filip, Drewa, Tomasz, Adamowicz, Jan, Wilamowski, Jacek, Ostrowski, Adam, Ostrowska, Magdalena, Kamecki, Krzysztof, Miklas, Marcin, Szlaga, Michal, Mikolajczak, Witold, Pokrywczynska, Marta, Juszczak, Kajetan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666019/
https://www.ncbi.nlm.nih.gov/pubmed/36397760
http://dx.doi.org/10.1155/2022/9495920
_version_ 1784831410404589568
author Kowalski, Filip
Drewa, Tomasz
Adamowicz, Jan
Wilamowski, Jacek
Ostrowski, Adam
Ostrowska, Magdalena
Kamecki, Krzysztof
Miklas, Marcin
Szlaga, Michal
Mikolajczak, Witold
Pokrywczynska, Marta
Juszczak, Kajetan
author_facet Kowalski, Filip
Drewa, Tomasz
Adamowicz, Jan
Wilamowski, Jacek
Ostrowski, Adam
Ostrowska, Magdalena
Kamecki, Krzysztof
Miklas, Marcin
Szlaga, Michal
Mikolajczak, Witold
Pokrywczynska, Marta
Juszczak, Kajetan
author_sort Kowalski, Filip
collection PubMed
description Bladder cancer tends to recur, making treatment one of the most expensive in oncology. The limited efficacy and high cost of adjuvant therapies in the treatment of bladder cancer prompt research on new drugs which could replace them. In vitro studies have established that antibiotics can have a cytostatic and cytotoxic effect on urinary bladder cancer cells. The objective of the study was to investigate the influence of antibiotics on the recurrence rate of bladder cancer. In a retrospective study, we analyzed a group of 199 patients with urinary bladder cancer from four urological centers. The study groups consisted of 40 patients who received ciprofloxacin and 83 patients who received beta-lactams as perioperative antimicrobial prophylaxis. The control group included 76 patients who did not get perioperative antimicrobial prophylaxis. The groups were analyzed for risk stratification, degree of malignancy, and size of the primary tumor. The average follow-up time was 24 months. The main focus of the study was to investigate the early recurrence rate of bladder cancer among studied groups, which could correlate with the effectiveness of currently used intravesical instillations. Additionally, cancer's early progression was examined. Regardless of the division used, the highest recurrence rate was found in the ciprofloxacin group. There were no statistical differences in the recurrence rate between patients who received beta-lactams and patients who did not receive any antibiotics. In addition, there were no differences due to the progression rate between the groups. Perioperative antibiotic administration does not influence the early recurrence rate in patients with nonmuscle invasive urothelial bladder cancer.
format Online
Article
Text
id pubmed-9666019
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-96660192022-11-16 Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate Kowalski, Filip Drewa, Tomasz Adamowicz, Jan Wilamowski, Jacek Ostrowski, Adam Ostrowska, Magdalena Kamecki, Krzysztof Miklas, Marcin Szlaga, Michal Mikolajczak, Witold Pokrywczynska, Marta Juszczak, Kajetan J Oncol Research Article Bladder cancer tends to recur, making treatment one of the most expensive in oncology. The limited efficacy and high cost of adjuvant therapies in the treatment of bladder cancer prompt research on new drugs which could replace them. In vitro studies have established that antibiotics can have a cytostatic and cytotoxic effect on urinary bladder cancer cells. The objective of the study was to investigate the influence of antibiotics on the recurrence rate of bladder cancer. In a retrospective study, we analyzed a group of 199 patients with urinary bladder cancer from four urological centers. The study groups consisted of 40 patients who received ciprofloxacin and 83 patients who received beta-lactams as perioperative antimicrobial prophylaxis. The control group included 76 patients who did not get perioperative antimicrobial prophylaxis. The groups were analyzed for risk stratification, degree of malignancy, and size of the primary tumor. The average follow-up time was 24 months. The main focus of the study was to investigate the early recurrence rate of bladder cancer among studied groups, which could correlate with the effectiveness of currently used intravesical instillations. Additionally, cancer's early progression was examined. Regardless of the division used, the highest recurrence rate was found in the ciprofloxacin group. There were no statistical differences in the recurrence rate between patients who received beta-lactams and patients who did not receive any antibiotics. In addition, there were no differences due to the progression rate between the groups. Perioperative antibiotic administration does not influence the early recurrence rate in patients with nonmuscle invasive urothelial bladder cancer. Hindawi 2022-11-08 /pmc/articles/PMC9666019/ /pubmed/36397760 http://dx.doi.org/10.1155/2022/9495920 Text en Copyright © 2022 Filip Kowalski et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kowalski, Filip
Drewa, Tomasz
Adamowicz, Jan
Wilamowski, Jacek
Ostrowski, Adam
Ostrowska, Magdalena
Kamecki, Krzysztof
Miklas, Marcin
Szlaga, Michal
Mikolajczak, Witold
Pokrywczynska, Marta
Juszczak, Kajetan
Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate
title Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate
title_full Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate
title_fullStr Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate
title_full_unstemmed Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate
title_short Influence of Antibiotic Administration on the Urinary Bladder Cancer Early Recurrence Rate
title_sort influence of antibiotic administration on the urinary bladder cancer early recurrence rate
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666019/
https://www.ncbi.nlm.nih.gov/pubmed/36397760
http://dx.doi.org/10.1155/2022/9495920
work_keys_str_mv AT kowalskifilip influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT drewatomasz influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT adamowiczjan influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT wilamowskijacek influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT ostrowskiadam influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT ostrowskamagdalena influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT kameckikrzysztof influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT miklasmarcin influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT szlagamichal influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT mikolajczakwitold influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT pokrywczynskamarta influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate
AT juszczakkajetan influenceofantibioticadministrationontheurinarybladdercancerearlyrecurrencerate