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The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis

Increasing evidence suggested obesity was associated with the risk of prostate cancer. Also, the association between prostate cancer risk and obesity has received much attention in recent years, but the results are still unclear. Therefore, the current systematic review and meta-analysis aimed to ev...

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Autores principales: Tzenios, Nikolaos, Tazanios, Mary E., Chahine, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666096/
https://www.ncbi.nlm.nih.gov/pubmed/36397423
http://dx.doi.org/10.1097/MD.0000000000030191
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author Tzenios, Nikolaos
Tazanios, Mary E.
Chahine, Mohamed
author_facet Tzenios, Nikolaos
Tazanios, Mary E.
Chahine, Mohamed
author_sort Tzenios, Nikolaos
collection PubMed
description Increasing evidence suggested obesity was associated with the risk of prostate cancer. Also, the association between prostate cancer risk and obesity has received much attention in recent years, but the results are still unclear. Therefore, the current systematic review and meta-analysis aimed to evaluate the impact of body mass index (BMI) on prostate cancer. METHODS: We systematically searched PubMed, Google Scholar, Scopus and Cochrane databases with the appropriate key terms to identify the eligible articles related to the impact of BMI on prostate cancer. The Newcastle-Ottawa checklist was used for the quality assessment of studies, and the meta-analysis was carried out using Review Manager 5.3. RESULTS: The present review includes 23 studies that fulfilled the criteria for inclusion. In the meta-analysis, a significant difference was observed between the obese and normal weight (P < .001) and 54% of obese has a risk compared to normal weight. Heterogeneity between the fifteen studies was high (I(2) = 100%). Test for overall effect: Z = 8.77 (P < .001) (odds ratio [OR] = 0.32 confidence interval [CI]: 0.25–0.42). However, there was no significant difference observed between the overweight and normal weight (P = .75). Heterogeneity between the fifteen studies is high (I(2) = 100%). CONCLUSION: Prostate cancer is a common malignancy that poses a threat to the health of men. Obesity is associated with a higher risk of death from prostate cancer based on the findings of the included studies. Furthermore, wherever possible, the impact of weight change on prostate cancer patient mortality should be investigated.
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spelling pubmed-96660962022-11-16 The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis Tzenios, Nikolaos Tazanios, Mary E. Chahine, Mohamed Medicine (Baltimore) 5700 Increasing evidence suggested obesity was associated with the risk of prostate cancer. Also, the association between prostate cancer risk and obesity has received much attention in recent years, but the results are still unclear. Therefore, the current systematic review and meta-analysis aimed to evaluate the impact of body mass index (BMI) on prostate cancer. METHODS: We systematically searched PubMed, Google Scholar, Scopus and Cochrane databases with the appropriate key terms to identify the eligible articles related to the impact of BMI on prostate cancer. The Newcastle-Ottawa checklist was used for the quality assessment of studies, and the meta-analysis was carried out using Review Manager 5.3. RESULTS: The present review includes 23 studies that fulfilled the criteria for inclusion. In the meta-analysis, a significant difference was observed between the obese and normal weight (P < .001) and 54% of obese has a risk compared to normal weight. Heterogeneity between the fifteen studies was high (I(2) = 100%). Test for overall effect: Z = 8.77 (P < .001) (odds ratio [OR] = 0.32 confidence interval [CI]: 0.25–0.42). However, there was no significant difference observed between the overweight and normal weight (P = .75). Heterogeneity between the fifteen studies is high (I(2) = 100%). CONCLUSION: Prostate cancer is a common malignancy that poses a threat to the health of men. Obesity is associated with a higher risk of death from prostate cancer based on the findings of the included studies. Furthermore, wherever possible, the impact of weight change on prostate cancer patient mortality should be investigated. Lippincott Williams & Wilkins 2022-11-11 /pmc/articles/PMC9666096/ /pubmed/36397423 http://dx.doi.org/10.1097/MD.0000000000030191 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Tzenios, Nikolaos
Tazanios, Mary E.
Chahine, Mohamed
The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis
title The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis
title_full The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis
title_fullStr The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis
title_full_unstemmed The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis
title_short The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis
title_sort impact of body mass index on prostate cancer: an updated systematic review and meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666096/
https://www.ncbi.nlm.nih.gov/pubmed/36397423
http://dx.doi.org/10.1097/MD.0000000000030191
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