Trends and frontiers in natural products for arthritis, 2000–2021: A bibliometric analysis

Arthritis has become one of the trouble diseases that upsets people. A growing number of studies have shown that natural products have great potential for the treatment of arthritis. However, few bibliometrics have been systematically studied in this area. This paper analyzes the literature data of natural products on the arthritis research, and the research hot spots and future research directions of the treatment of arthritis by natural products were explored. METHOD: Through CiteSpace, VOSviewer software and Bibliometricx under the R language environment, the article and review literatures on the treatment of arthritis with natural drugs in the Web of Science core collection database were analyzed by bibliometric analysis. RESULTS: On December 28, 2021, a total of 2102 records were retrieved, 81.69% publications were issued in 2012 to 2021, mainly in China-dominated Asian countries, with cooperation among countries. The analysis of the number of articles published by institutions shows that the number of articles published by China Academy of Chinese Medical Sciences is up to 82. Lu, Aiping and Smolen, JS are the authors with the highest citation frequency and co-citation frequency. Keywords analysis showed that the research of natural drugs mainly focused on gene expression, anti-inflammatory and other mechanisms and signaling pathways. With the progress of science and technology and the integration of multi-disciplines, the research on natural drugs for arthritis will be more in-depth and specific. CONCLUSION: In this study, literature metrology analysis was conducted on natural products in the treatment of arthritis, in order to grasp the background, trends and frontiers of the research, and predict possible research hotspots in the future. It is expected to provide some reference value and direction for future scholars in this field.