Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report

Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. METHODS: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplant...

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Detalles Bibliográficos
Autores principales: Fei, Hairong, Liu, Xiaodan, Sun, Lingjie, Shi, Xue, Wang, Wei, Zhao, Hongguo, Zhao, Chunting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
4800
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666177/
https://www.ncbi.nlm.nih.gov/pubmed/36397380
http://dx.doi.org/10.1097/MD.0000000000031594
Descripción
Sumario:Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. METHODS: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor-modified T cells treatment. RESULTS: During transplantation, disseminated Fusarium infection occurred, involving the skin, liver, spleen and central nervous system, and the patient eventually died. CONCLUSIONS: Early identification of Fusarium infection based on the characteristic rash and timely antifungal treatment can improve the cure rate.

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