Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report

Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. METHODS: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplant...

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Autores principales: Fei, Hairong, Liu, Xiaodan, Sun, Lingjie, Shi, Xue, Wang, Wei, Zhao, Hongguo, Zhao, Chunting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
4800
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666177/
https://www.ncbi.nlm.nih.gov/pubmed/36397380
http://dx.doi.org/10.1097/MD.0000000000031594
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author Fei, Hairong
Liu, Xiaodan
Sun, Lingjie
Shi, Xue
Wang, Wei
Zhao, Hongguo
Zhao, Chunting
author_facet Fei, Hairong
Liu, Xiaodan
Sun, Lingjie
Shi, Xue
Wang, Wei
Zhao, Hongguo
Zhao, Chunting
author_sort Fei, Hairong
collection PubMed
description Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. METHODS: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor-modified T cells treatment. RESULTS: During transplantation, disseminated Fusarium infection occurred, involving the skin, liver, spleen and central nervous system, and the patient eventually died. CONCLUSIONS: Early identification of Fusarium infection based on the characteristic rash and timely antifungal treatment can improve the cure rate.
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spelling pubmed-96661772022-11-16 Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report Fei, Hairong Liu, Xiaodan Sun, Lingjie Shi, Xue Wang, Wei Zhao, Hongguo Zhao, Chunting Medicine (Baltimore) 4800 Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. METHODS: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor-modified T cells treatment. RESULTS: During transplantation, disseminated Fusarium infection occurred, involving the skin, liver, spleen and central nervous system, and the patient eventually died. CONCLUSIONS: Early identification of Fusarium infection based on the characteristic rash and timely antifungal treatment can improve the cure rate. Lippincott Williams & Wilkins 2022-11-11 /pmc/articles/PMC9666177/ /pubmed/36397380 http://dx.doi.org/10.1097/MD.0000000000031594 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4800
Fei, Hairong
Liu, Xiaodan
Sun, Lingjie
Shi, Xue
Wang, Wei
Zhao, Hongguo
Zhao, Chunting
Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report
title Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report
title_full Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report
title_fullStr Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report
title_full_unstemmed Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report
title_short Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report
title_sort disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after cart: a case report
topic 4800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666177/
https://www.ncbi.nlm.nih.gov/pubmed/36397380
http://dx.doi.org/10.1097/MD.0000000000031594
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