BRCA2 gene mutation in cancer

Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological function...

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Detalles Bibliográficos
Autores principales: Xie, Chunbao, Luo, Jiangrong, He, Yangjun, Jiang, Lingxi, Zhong, Ling, Shi, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
5700
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666215/
https://www.ncbi.nlm.nih.gov/pubmed/36397405
http://dx.doi.org/10.1097/MD.0000000000031705
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author Xie, Chunbao
Luo, Jiangrong
He, Yangjun
Jiang, Lingxi
Zhong, Ling
Shi, Yi
author_facet Xie, Chunbao
Luo, Jiangrong
He, Yangjun
Jiang, Lingxi
Zhong, Ling
Shi, Yi
author_sort Xie, Chunbao
collection PubMed
description Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy.
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spelling pubmed-96662152022-11-16 BRCA2 gene mutation in cancer Xie, Chunbao Luo, Jiangrong He, Yangjun Jiang, Lingxi Zhong, Ling Shi, Yi Medicine (Baltimore) 5700 Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy. Lippincott Williams & Wilkins 2022-11-11 /pmc/articles/PMC9666215/ /pubmed/36397405 http://dx.doi.org/10.1097/MD.0000000000031705 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Xie, Chunbao
Luo, Jiangrong
He, Yangjun
Jiang, Lingxi
Zhong, Ling
Shi, Yi
BRCA2 gene mutation in cancer
title BRCA2 gene mutation in cancer
title_full BRCA2 gene mutation in cancer
title_fullStr BRCA2 gene mutation in cancer
title_full_unstemmed BRCA2 gene mutation in cancer
title_short BRCA2 gene mutation in cancer
title_sort brca2 gene mutation in cancer
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666215/
https://www.ncbi.nlm.nih.gov/pubmed/36397405
http://dx.doi.org/10.1097/MD.0000000000031705
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AT luojiangrong brca2genemutationincancer
AT heyangjun brca2genemutationincancer
AT jianglingxi brca2genemutationincancer
AT zhongling brca2genemutationincancer
AT shiyi brca2genemutationincancer

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