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Vitamin B12 as a novel risk biomarker of spinal fractures
Spinal fractures are common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and a high risk of spinal fractures. However, the underlying factors for spinal fractures in patients with osteoporosis are unclear. A total of 105 patients wi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666216/ https://www.ncbi.nlm.nih.gov/pubmed/36397346 http://dx.doi.org/10.1097/MD.0000000000030796 |
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author | Li, Zheng Zheng, Rugeng Xue, Hui Zhu, Hao |
author_facet | Li, Zheng Zheng, Rugeng Xue, Hui Zhu, Hao |
author_sort | Li, Zheng |
collection | PubMed |
description | Spinal fractures are common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and a high risk of spinal fractures. However, the underlying factors for spinal fractures in patients with osteoporosis are unclear. A total of 105 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And vitamin B12, vitamin B2, vitamin A, and vitamin B9 in the blood were tested. Pearson’s chi-squared and spearman tests were performed to analyze the correlation between spinal fractures and relative parameters. Univariate and multivariate logistic regression, univariate and multivariate Cox proportional hazards regression analysis. There exists strong relation between the expression level of vitamin B12 and spinal fractures. Pearson’s chi-square and Spearman correlation test showed a strong association between vitamin B12 and vitamin B9 and a spinal fracture. Univariate logistic regression analysis showed that vitamin B12 and vitamin B9 were significantly associated with a spinal fracture. Multivariate logistic regression analysis showed that vitamin B12 was associated considerably with a spinal fracture. In addition, Cox regression analysis showed that vitamin B12 expression was significantly associated with maintenance time from recovery to recurrence (MTRR) of spinal fractures in patients with osteoporosis. Enhanced vitamin B12 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of a spinal fracture. The higher the vitamin B12, the higher the risk of spinal fracture and the shorter the time to spinal fracture recurrence. |
format | Online Article Text |
id | pubmed-9666216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-96662162022-11-16 Vitamin B12 as a novel risk biomarker of spinal fractures Li, Zheng Zheng, Rugeng Xue, Hui Zhu, Hao Medicine (Baltimore) 3700 Spinal fractures are common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and a high risk of spinal fractures. However, the underlying factors for spinal fractures in patients with osteoporosis are unclear. A total of 105 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And vitamin B12, vitamin B2, vitamin A, and vitamin B9 in the blood were tested. Pearson’s chi-squared and spearman tests were performed to analyze the correlation between spinal fractures and relative parameters. Univariate and multivariate logistic regression, univariate and multivariate Cox proportional hazards regression analysis. There exists strong relation between the expression level of vitamin B12 and spinal fractures. Pearson’s chi-square and Spearman correlation test showed a strong association between vitamin B12 and vitamin B9 and a spinal fracture. Univariate logistic regression analysis showed that vitamin B12 and vitamin B9 were significantly associated with a spinal fracture. Multivariate logistic regression analysis showed that vitamin B12 was associated considerably with a spinal fracture. In addition, Cox regression analysis showed that vitamin B12 expression was significantly associated with maintenance time from recovery to recurrence (MTRR) of spinal fractures in patients with osteoporosis. Enhanced vitamin B12 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of a spinal fracture. The higher the vitamin B12, the higher the risk of spinal fracture and the shorter the time to spinal fracture recurrence. Lippincott Williams & Wilkins 2022-11-11 /pmc/articles/PMC9666216/ /pubmed/36397346 http://dx.doi.org/10.1097/MD.0000000000030796 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 3700 Li, Zheng Zheng, Rugeng Xue, Hui Zhu, Hao Vitamin B12 as a novel risk biomarker of spinal fractures |
title | Vitamin B12 as a novel risk biomarker of spinal fractures |
title_full | Vitamin B12 as a novel risk biomarker of spinal fractures |
title_fullStr | Vitamin B12 as a novel risk biomarker of spinal fractures |
title_full_unstemmed | Vitamin B12 as a novel risk biomarker of spinal fractures |
title_short | Vitamin B12 as a novel risk biomarker of spinal fractures |
title_sort | vitamin b12 as a novel risk biomarker of spinal fractures |
topic | 3700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666216/ https://www.ncbi.nlm.nih.gov/pubmed/36397346 http://dx.doi.org/10.1097/MD.0000000000030796 |
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