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Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review

Accumulating evidence supports the active involvement of vascular inflammation in atherosclerosis pathogenesis. Vascular inflammatory events within atherosclerotic plaques are predominated by innate antigen-presenting cells (APCs), including dendritic cells, macrophages, and adaptive immune cells su...

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Autores principales: Yang, Mao, Tian, Simeng, Lin, Zhoujun, Fu, Zhenkun, Li, Chenggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666218/
https://www.ncbi.nlm.nih.gov/pubmed/36397436
http://dx.doi.org/10.1097/MD.0000000000031667
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author Yang, Mao
Tian, Simeng
Lin, Zhoujun
Fu, Zhenkun
Li, Chenggang
author_facet Yang, Mao
Tian, Simeng
Lin, Zhoujun
Fu, Zhenkun
Li, Chenggang
author_sort Yang, Mao
collection PubMed
description Accumulating evidence supports the active involvement of vascular inflammation in atherosclerosis pathogenesis. Vascular inflammatory events within atherosclerotic plaques are predominated by innate antigen-presenting cells (APCs), including dendritic cells, macrophages, and adaptive immune cells such as T lymphocytes. The interaction between APCs and T cells is essential for the initiation and progression of vascular inflammation during atherosclerosis formation. B7-CD28 family members that provide either costimulatory or coinhibitory signals to T cells are important mediators of the cross-talk between APCs and T cells. The balance of different functional members of the B7-CD28 family shapes T cell responses during inflammation. Recent studies from both mouse and preclinical models have shown that targeting costimulatory molecules on APCs and T cells may be effective in treating vascular inflammatory diseases, especially atherosclerosis. In this review, we summarize recent advances in understanding how APC and T cells are involved in the pathogenesis of atherosclerosis by focusing on B7-CD28 family members and provide insight into the immunotherapeutic potential of targeting B7-CD28 family members in atherosclerosis.
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spelling pubmed-96662182022-11-16 Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review Yang, Mao Tian, Simeng Lin, Zhoujun Fu, Zhenkun Li, Chenggang Medicine (Baltimore) 3400 Accumulating evidence supports the active involvement of vascular inflammation in atherosclerosis pathogenesis. Vascular inflammatory events within atherosclerotic plaques are predominated by innate antigen-presenting cells (APCs), including dendritic cells, macrophages, and adaptive immune cells such as T lymphocytes. The interaction between APCs and T cells is essential for the initiation and progression of vascular inflammation during atherosclerosis formation. B7-CD28 family members that provide either costimulatory or coinhibitory signals to T cells are important mediators of the cross-talk between APCs and T cells. The balance of different functional members of the B7-CD28 family shapes T cell responses during inflammation. Recent studies from both mouse and preclinical models have shown that targeting costimulatory molecules on APCs and T cells may be effective in treating vascular inflammatory diseases, especially atherosclerosis. In this review, we summarize recent advances in understanding how APC and T cells are involved in the pathogenesis of atherosclerosis by focusing on B7-CD28 family members and provide insight into the immunotherapeutic potential of targeting B7-CD28 family members in atherosclerosis. Lippincott Williams & Wilkins 2022-11-11 /pmc/articles/PMC9666218/ /pubmed/36397436 http://dx.doi.org/10.1097/MD.0000000000031667 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 3400
Yang, Mao
Tian, Simeng
Lin, Zhoujun
Fu, Zhenkun
Li, Chenggang
Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
title Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
title_full Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
title_fullStr Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
title_full_unstemmed Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
title_short Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
title_sort costimulatory and coinhibitory molecules of b7-cd28 family in cardiovascular atherosclerosis: a review
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666218/
https://www.ncbi.nlm.nih.gov/pubmed/36397436
http://dx.doi.org/10.1097/MD.0000000000031667
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