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Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients
A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666267/ https://www.ncbi.nlm.nih.gov/pubmed/36406863 http://dx.doi.org/10.1016/j.isci.2022.105608 |
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author | Klingler, Jéromine Lambert, Gregory S. Bandres, Juan C. Emami-Gorizi, Rozita Nádas, Arthur Oguntuyo, Kasopefoluwa Y. Amanat, Fatima Bermúdez-González, Maria C. Gleason, Charles Kleiner, Giulio Simon, Viviana Lee, Benhur Zolla-Pazner, Susan Upadhyay, Chitra Hioe, Catarina E. |
author_facet | Klingler, Jéromine Lambert, Gregory S. Bandres, Juan C. Emami-Gorizi, Rozita Nádas, Arthur Oguntuyo, Kasopefoluwa Y. Amanat, Fatima Bermúdez-González, Maria C. Gleason, Charles Kleiner, Giulio Simon, Viviana Lee, Benhur Zolla-Pazner, Susan Upadhyay, Chitra Hioe, Catarina E. |
author_sort | Klingler, Jéromine |
collection | PubMed |
description | A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19. |
format | Online Article Text |
id | pubmed-9666267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96662672022-11-16 Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients Klingler, Jéromine Lambert, Gregory S. Bandres, Juan C. Emami-Gorizi, Rozita Nádas, Arthur Oguntuyo, Kasopefoluwa Y. Amanat, Fatima Bermúdez-González, Maria C. Gleason, Charles Kleiner, Giulio Simon, Viviana Lee, Benhur Zolla-Pazner, Susan Upadhyay, Chitra Hioe, Catarina E. iScience Article A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19. Elsevier 2022-11-16 /pmc/articles/PMC9666267/ /pubmed/36406863 http://dx.doi.org/10.1016/j.isci.2022.105608 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Klingler, Jéromine Lambert, Gregory S. Bandres, Juan C. Emami-Gorizi, Rozita Nádas, Arthur Oguntuyo, Kasopefoluwa Y. Amanat, Fatima Bermúdez-González, Maria C. Gleason, Charles Kleiner, Giulio Simon, Viviana Lee, Benhur Zolla-Pazner, Susan Upadhyay, Chitra Hioe, Catarina E. Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients |
title | Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients |
title_full | Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients |
title_fullStr | Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients |
title_full_unstemmed | Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients |
title_short | Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients |
title_sort | immune profiles to distinguish hospitalized versus ambulatory covid-19 cases in older patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666267/ https://www.ncbi.nlm.nih.gov/pubmed/36406863 http://dx.doi.org/10.1016/j.isci.2022.105608 |
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