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Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients

A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse...

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Autores principales: Klingler, Jéromine, Lambert, Gregory S., Bandres, Juan C., Emami-Gorizi, Rozita, Nádas, Arthur, Oguntuyo, Kasopefoluwa Y., Amanat, Fatima, Bermúdez-González, Maria C., Gleason, Charles, Kleiner, Giulio, Simon, Viviana, Lee, Benhur, Zolla-Pazner, Susan, Upadhyay, Chitra, Hioe, Catarina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666267/
https://www.ncbi.nlm.nih.gov/pubmed/36406863
http://dx.doi.org/10.1016/j.isci.2022.105608
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author Klingler, Jéromine
Lambert, Gregory S.
Bandres, Juan C.
Emami-Gorizi, Rozita
Nádas, Arthur
Oguntuyo, Kasopefoluwa Y.
Amanat, Fatima
Bermúdez-González, Maria C.
Gleason, Charles
Kleiner, Giulio
Simon, Viviana
Lee, Benhur
Zolla-Pazner, Susan
Upadhyay, Chitra
Hioe, Catarina E.
author_facet Klingler, Jéromine
Lambert, Gregory S.
Bandres, Juan C.
Emami-Gorizi, Rozita
Nádas, Arthur
Oguntuyo, Kasopefoluwa Y.
Amanat, Fatima
Bermúdez-González, Maria C.
Gleason, Charles
Kleiner, Giulio
Simon, Viviana
Lee, Benhur
Zolla-Pazner, Susan
Upadhyay, Chitra
Hioe, Catarina E.
author_sort Klingler, Jéromine
collection PubMed
description A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19.
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spelling pubmed-96662672022-11-16 Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients Klingler, Jéromine Lambert, Gregory S. Bandres, Juan C. Emami-Gorizi, Rozita Nádas, Arthur Oguntuyo, Kasopefoluwa Y. Amanat, Fatima Bermúdez-González, Maria C. Gleason, Charles Kleiner, Giulio Simon, Viviana Lee, Benhur Zolla-Pazner, Susan Upadhyay, Chitra Hioe, Catarina E. iScience Article A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19. Elsevier 2022-11-16 /pmc/articles/PMC9666267/ /pubmed/36406863 http://dx.doi.org/10.1016/j.isci.2022.105608 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Klingler, Jéromine
Lambert, Gregory S.
Bandres, Juan C.
Emami-Gorizi, Rozita
Nádas, Arthur
Oguntuyo, Kasopefoluwa Y.
Amanat, Fatima
Bermúdez-González, Maria C.
Gleason, Charles
Kleiner, Giulio
Simon, Viviana
Lee, Benhur
Zolla-Pazner, Susan
Upadhyay, Chitra
Hioe, Catarina E.
Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients
title Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients
title_full Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients
title_fullStr Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients
title_full_unstemmed Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients
title_short Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients
title_sort immune profiles to distinguish hospitalized versus ambulatory covid-19 cases in older patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666267/
https://www.ncbi.nlm.nih.gov/pubmed/36406863
http://dx.doi.org/10.1016/j.isci.2022.105608
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