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Clinical prospects of WRN inhibition as a treatment for MSI tumours

The discovery of synthetic lethal interactions with genetic deficiencies in cancers has highlighted several candidate targets for drug development, with variable clinical success. Recent work has unveiled a promising synthetic lethal interaction between inactivation/inhibition of the WRN DNA helicas...

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Detalles Bibliográficos
Autores principales:	Morales-Juarez, David A., Jackson, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666358/ https://www.ncbi.nlm.nih.gov/pubmed/36379964 http://dx.doi.org/10.1038/s41698-022-00319-y

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