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Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus

Psychostimulants, such as methamphetamine (METH) can induce structural remodeling of synapses by remodeling presynaptic and postsynaptic morphology. Escalating or long-lasting high dose METH accounts for neurodegeneration by targeting multiple neurotransmitters. However, the effects of low dose METH...

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Autores principales: Ding, Jiuyang, Huang, Jian, Tang, Xiang, Shen, Lingyi, Hu, Shanshan, He, Jiaojiao, Liu, Ting, Yu, Zhixing, Liu, Yubo, Wang, Qiyan, Wang, Jiawen, Zhao, Na, Qi, Xiaolan, Huang, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666390/
https://www.ncbi.nlm.nih.gov/pubmed/36406748
http://dx.doi.org/10.3389/fncel.2022.1003617
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author Ding, Jiuyang
Huang, Jian
Tang, Xiang
Shen, Lingyi
Hu, Shanshan
He, Jiaojiao
Liu, Ting
Yu, Zhixing
Liu, Yubo
Wang, Qiyan
Wang, Jiawen
Zhao, Na
Qi, Xiaolan
Huang, Jiang
author_facet Ding, Jiuyang
Huang, Jian
Tang, Xiang
Shen, Lingyi
Hu, Shanshan
He, Jiaojiao
Liu, Ting
Yu, Zhixing
Liu, Yubo
Wang, Qiyan
Wang, Jiawen
Zhao, Na
Qi, Xiaolan
Huang, Jiang
author_sort Ding, Jiuyang
collection PubMed
description Psychostimulants, such as methamphetamine (METH) can induce structural remodeling of synapses by remodeling presynaptic and postsynaptic morphology. Escalating or long-lasting high dose METH accounts for neurodegeneration by targeting multiple neurotransmitters. However, the effects of low dose METH on synaptic structure and the modulation mechanism remain elusive. This study aims to assess the effects of low dose (2 mg/kg) and high dose (10 mg/kg) of METH on synaptic structure alternation in hippocampus and prefrontal cortex (PFC) and to reveal the underlying mechanism involved in the process. Low dose METH promoted spine formation, synaptic number increase, post-synaptic density length elongation, and memory function. High dose of METH induced synaptic degeneration, neuronal number loss and memory impairment. Moreover, high dose, but not low dose, of METH caused gliosis in PFC and hippocampus. Mechanism-wise, low dose METH inactivated ras-related C3 botulinum toxin substrate 1 (Rac1) and activated cell division control protein 42 homolog (Cdc42); whereas high dose METH inactivated Cdc42 and activated Rac1. We provided evidence that low and high doses of METH differentially regulate synaptic plasticity in cortex and hippocampus.
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spelling pubmed-96663902022-11-17 Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus Ding, Jiuyang Huang, Jian Tang, Xiang Shen, Lingyi Hu, Shanshan He, Jiaojiao Liu, Ting Yu, Zhixing Liu, Yubo Wang, Qiyan Wang, Jiawen Zhao, Na Qi, Xiaolan Huang, Jiang Front Cell Neurosci Neuroscience Psychostimulants, such as methamphetamine (METH) can induce structural remodeling of synapses by remodeling presynaptic and postsynaptic morphology. Escalating or long-lasting high dose METH accounts for neurodegeneration by targeting multiple neurotransmitters. However, the effects of low dose METH on synaptic structure and the modulation mechanism remain elusive. This study aims to assess the effects of low dose (2 mg/kg) and high dose (10 mg/kg) of METH on synaptic structure alternation in hippocampus and prefrontal cortex (PFC) and to reveal the underlying mechanism involved in the process. Low dose METH promoted spine formation, synaptic number increase, post-synaptic density length elongation, and memory function. High dose of METH induced synaptic degeneration, neuronal number loss and memory impairment. Moreover, high dose, but not low dose, of METH caused gliosis in PFC and hippocampus. Mechanism-wise, low dose METH inactivated ras-related C3 botulinum toxin substrate 1 (Rac1) and activated cell division control protein 42 homolog (Cdc42); whereas high dose METH inactivated Cdc42 and activated Rac1. We provided evidence that low and high doses of METH differentially regulate synaptic plasticity in cortex and hippocampus. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666390/ /pubmed/36406748 http://dx.doi.org/10.3389/fncel.2022.1003617 Text en Copyright © 2022 Ding, Huang, Tang, Shen, Hu, He, Liu, Yu, Liu, Wang, Wang, Zhao, Qi and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ding, Jiuyang
Huang, Jian
Tang, Xiang
Shen, Lingyi
Hu, Shanshan
He, Jiaojiao
Liu, Ting
Yu, Zhixing
Liu, Yubo
Wang, Qiyan
Wang, Jiawen
Zhao, Na
Qi, Xiaolan
Huang, Jiang
Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus
title Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus
title_full Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus
title_fullStr Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus
title_full_unstemmed Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus
title_short Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus
title_sort low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666390/
https://www.ncbi.nlm.nih.gov/pubmed/36406748
http://dx.doi.org/10.3389/fncel.2022.1003617
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