Cargando…

ECM1 regulates the resistance of colorectal cancer to 5-FU treatment by modulating apoptotic cell death and epithelial-mesenchymal transition induction

5-Fluorouracil (5-FU) chemoresistance is a persistent impediment to the efficient treatment of many types of cancer, yet the molecular mechanisms underlying such resistance remain incompletely understood. Here we found CRC patients resistant to 5-FU treatment exhibited increased extracellular matrix...

Descripción completa

Detalles Bibliográficos
Autores principales:	Long, Sirui, Wang, Jie, Weng, Fanbin, Pei, Zhigang, Zhou, Shixian, Sun, Guiyin, Xiang, Debing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666402/ https://www.ncbi.nlm.nih.gov/pubmed/36408224 http://dx.doi.org/10.3389/fphar.2022.1005915

Ejemplares similares

Extracellular Matrix Protein 1 Regulates Colorectal Cancer Cell Proliferative, Migratory, Invasive and Epithelial-Mesenchymal Transition Activities Through the PI3K/AKT/GSK3β/Snail Signaling Axis
por: Long, Sirui, et al.
Publicado: (2022)

DYRK2 downregulation in colorectal cancer leads to epithelial–mesenchymal transition induction and chemoresistance
por: Wu, Chunrong, et al.
Publicado: (2022)

Coptidis Rhizoma Suppresses Metastatic Behavior by Inhibiting TGF-β-Mediated Epithelial-Mesenchymal Transition in 5-FU-Resistant HCT116 Cells
por: Kang, Yong-Hwi, et al.
Publicado: (2022)

Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition
por: Avila-Carrasco, Lorena, et al.
Publicado: (2019)

Tackle Epithelial-Mesenchymal Transition With Epigenetic Drugs in Cancer
por: Dong, Bo, et al.
Publicado: (2020)

Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
por: Lovisa, Sara
Publicado: (2021)

microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney
por: Srivastava, Swayam Prakash, et al.
Publicado: (2019)

Harnessing the ECM Microenvironment to Ameliorate Mesenchymal Stromal Cell-Based Therapy in Chronic Lung Diseases
por: Elowsson Rendin, Linda, et al.
Publicado: (2021)

ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition
por: Chen, Hao, et al.
Publicado: (2016)

Erratum: microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney
Publicado: (2020)

Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge
por: Fintha, Attila, et al.
Publicado: (2019)

The Role of MicroRNA in the Regulation of Tumor Epithelial–Mesenchymal Transition
por: Feng, Jing, et al.
Publicado: (2022)

Nanoapproaches to Modifying Epigenetics of Epithelial Mesenchymal Transition for Treatment of Pulmonary Fibrosis
por: Skibba, Melissa, et al.
Publicado: (2020)

Colocynth Extracts Prevent Epithelial to Mesenchymal Transition and Stemness of Breast Cancer Cells
por: Chowdhury, Kaushik, et al.
Publicado: (2017)

Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition
por: Skibba, Melissa, et al.
Publicado: (2017)

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition
por: Pi, Peng, et al.
Publicado: (2023)

Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
por: Yang, Hui-Wen, et al.
Publicado: (2023)

Proteoglycans in Biomedicine: Resurgence of an Underexploited Class of ECM Molecules
por: Walimbe, Tanaya, et al.
Publicado: (2020)

Editorial: Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis
por: Battistelli, Cecilia, et al.
Publicado: (2020)

Anticancer Activity of Garcinia morella on T-Cell Murine Lymphoma Via Apoptotic Induction
por: Choudhury, Bhaswati, et al.
Publicado: (2016)

Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells
por: Chen, Huang-Chi, et al.
Publicado: (2022)

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1
por: Wang, Yuchen, et al.
Publicado: (2019)

cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition
por: Padmanabhan, Chandrasekhar, et al.
Publicado: (2017)

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition
por: Sulaiman, Siti A., et al.
Publicado: (2016)

Blockade of Eosinophil-Induced Bronchial Epithelial-Mesenchymal Transition with a Geranyl Acetophenone in a Coculture Model
por: Lee, Yu Z., et al.
Publicado: (2017)

How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress—Therapeutic Implications
por: Marcucci, Fabrizio, et al.
Publicado: (2018)

Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis
por: Marquez-Exposito, Laura, et al.
Publicado: (2018)

A Novel Epithelial-Mesenchymal Transition Gene Signature Correlated With Prognosis, and Immune Infiltration in Hepatocellular Carcinoma
por: Kong, Weihao, et al.
Publicado: (2022)

Identification of molecular patterns and prognostic models of epithelial–mesenchymal transition- and immune-combined index in the gastric cancer
por: Zhang, Xiuyuan, et al.
Publicado: (2022)

Editorial: Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis, volume II
por: Battistelli, Cecilia, et al.
Publicado: (2022)

A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2
por: Deng, Youyuan, et al.
Publicado: (2021)

Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy
por: Chang, Yun-peng, et al.
Publicado: (2017)

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1
por: Yang, Yong, et al.
Publicado: (2020)

Huangqin Tang Interference With Colitis Associated Colorectal Cancer Through Regulation of Epithelial Mesenchymal Transition and Cell Cycle
por: Ma, Xuran, et al.
Publicado: (2022)

Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells
por: Buhrmann, Constanze, et al.
Publicado: (2021)

Role of ARID1A in epithelial-mesenchymal transition in breast cancer and its effect on cell sensitivity to 5FU
por: Wang, Tangshun, et al.
Publicado: (2020)

Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1
por: Dai, Zhang’an, et al.
Publicado: (2021)

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy
por: Yang, Hao, et al.
Publicado: (2022)

Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition
por: Lin, Lianjie, et al.
Publicado: (2016)

Requirement of Histone Deacetylase 6 for Interleukin-6 Induced Epithelial-Mesenchymal Transition, Proliferation, and Migration of Peritoneal Mesothelial Cells
por: Shi, Yingfeng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dqbhc9d6hrr938pbej96lquvfr