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Mysterious long noncoding RNAs and their relationships to human disease
Increasingly studies have shown that the formation mechanism of many human diseases is very complex, which is determined by environmental factors and genetic factors rather than fully following Mendel’s genetic law of inheritance. Long non-coding RNA (lncRNA) is a class of endogenous non-protein cod...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666423/ https://www.ncbi.nlm.nih.gov/pubmed/36406273 http://dx.doi.org/10.3389/fmolb.2022.950408 |
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author | Li, Wenchao Wang, Yang Yang Xiao, Lifei Ding, Jiangwei Wang, Lei Wang, Feng Sun, Tao |
author_facet | Li, Wenchao Wang, Yang Yang Xiao, Lifei Ding, Jiangwei Wang, Lei Wang, Feng Sun, Tao |
author_sort | Li, Wenchao |
collection | PubMed |
description | Increasingly studies have shown that the formation mechanism of many human diseases is very complex, which is determined by environmental factors and genetic factors rather than fully following Mendel’s genetic law of inheritance. Long non-coding RNA (lncRNA) is a class of endogenous non-protein coding RNA with a length greater than 200 nt, which has attracted much attention in recent years. Studies have shown that lncRNAs have a wide range of biological functions, such as roles in gene imprinting, cell cycle progression, apoptosis, senescence, cell differentiation, and stress responses, and that they regulate the life processes of mammals at various levels, such as epigenetic transcription, processing, modification, transport, translation and degradation. Analyzing the characteristics of lncRNAs and revealing their internal roles can not only deepen our understanding of human physiological and pathological processes, but also provide new ideas and solutions for the diagnosis, prevention and treatment of some diseases. This article mainly reviews the biological characteristics of lncRNAs and their relationship with some diseases, so as to provide references for the related research of lncRNAs. |
format | Online Article Text |
id | pubmed-9666423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96664232022-11-17 Mysterious long noncoding RNAs and their relationships to human disease Li, Wenchao Wang, Yang Yang Xiao, Lifei Ding, Jiangwei Wang, Lei Wang, Feng Sun, Tao Front Mol Biosci Molecular Biosciences Increasingly studies have shown that the formation mechanism of many human diseases is very complex, which is determined by environmental factors and genetic factors rather than fully following Mendel’s genetic law of inheritance. Long non-coding RNA (lncRNA) is a class of endogenous non-protein coding RNA with a length greater than 200 nt, which has attracted much attention in recent years. Studies have shown that lncRNAs have a wide range of biological functions, such as roles in gene imprinting, cell cycle progression, apoptosis, senescence, cell differentiation, and stress responses, and that they regulate the life processes of mammals at various levels, such as epigenetic transcription, processing, modification, transport, translation and degradation. Analyzing the characteristics of lncRNAs and revealing their internal roles can not only deepen our understanding of human physiological and pathological processes, but also provide new ideas and solutions for the diagnosis, prevention and treatment of some diseases. This article mainly reviews the biological characteristics of lncRNAs and their relationship with some diseases, so as to provide references for the related research of lncRNAs. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666423/ /pubmed/36406273 http://dx.doi.org/10.3389/fmolb.2022.950408 Text en Copyright © 2022 Li, Wang, Xiao, Ding, Wang, Wang and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Li, Wenchao Wang, Yang Yang Xiao, Lifei Ding, Jiangwei Wang, Lei Wang, Feng Sun, Tao Mysterious long noncoding RNAs and their relationships to human disease |
title | Mysterious long noncoding RNAs and their relationships to human disease |
title_full | Mysterious long noncoding RNAs and their relationships to human disease |
title_fullStr | Mysterious long noncoding RNAs and their relationships to human disease |
title_full_unstemmed | Mysterious long noncoding RNAs and their relationships to human disease |
title_short | Mysterious long noncoding RNAs and their relationships to human disease |
title_sort | mysterious long noncoding rnas and their relationships to human disease |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666423/ https://www.ncbi.nlm.nih.gov/pubmed/36406273 http://dx.doi.org/10.3389/fmolb.2022.950408 |
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