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Future opportunities for the Athlete Biological Passport

The Athlete Biological Passport (ABP) was introduced to complement the direct anti-doping approach by indirectly outlining the possible use of prohibited substances or methods in sports. The ABP proved its effectiveness, at least through a deterrent effect, even though the matrices used for longitud...

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Autores principales: Krumm, Bastien, Botrè, Francesco, Saugy, Jonas J., Faiss, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666424/
https://www.ncbi.nlm.nih.gov/pubmed/36406774
http://dx.doi.org/10.3389/fspor.2022.986875
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author Krumm, Bastien
Botrè, Francesco
Saugy, Jonas J.
Faiss, Raphael
author_facet Krumm, Bastien
Botrè, Francesco
Saugy, Jonas J.
Faiss, Raphael
author_sort Krumm, Bastien
collection PubMed
description The Athlete Biological Passport (ABP) was introduced to complement the direct anti-doping approach by indirectly outlining the possible use of prohibited substances or methods in sports. The ABP proved its effectiveness, at least through a deterrent effect, even though the matrices used for longitudinal monitoring (urine and blood) are subject to many intrinsic (e.g., genetic) and extrinsic (e.g., environmental conditions) confounding factors. In that context, new and more specific biomarkers are currently under development to enhance both the sensitivity and the specificity of the ABP. Multiple strategies are presently being explored to improve this longitudinal monitoring, with the development of the current modules, the investigation of new strategies, or the screening of new types of doping. Nevertheless, due to the variability induced by indirect biomarkers, the consideration of confounding factors should continuously support this research. Beyond tremendous advances in analytical sensitivity, machine learning-based approaches seem inevitable to facilitate an expert interpretation of numerous biological profiles and promote anti-doping efforts. This perspective article highlights the current innovations of the Athlete Biological Passport that seem the most promising. Through different research axes, this short manuscript provides an opportunity to bring together approaches that are more widely exploited (e.g., omics strategies) and others in the early stages of investigation (e.g., artificial intelligence) seeking to develop the ABP.
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spelling pubmed-96664242022-11-17 Future opportunities for the Athlete Biological Passport Krumm, Bastien Botrè, Francesco Saugy, Jonas J. Faiss, Raphael Front Sports Act Living Sports and Active Living The Athlete Biological Passport (ABP) was introduced to complement the direct anti-doping approach by indirectly outlining the possible use of prohibited substances or methods in sports. The ABP proved its effectiveness, at least through a deterrent effect, even though the matrices used for longitudinal monitoring (urine and blood) are subject to many intrinsic (e.g., genetic) and extrinsic (e.g., environmental conditions) confounding factors. In that context, new and more specific biomarkers are currently under development to enhance both the sensitivity and the specificity of the ABP. Multiple strategies are presently being explored to improve this longitudinal monitoring, with the development of the current modules, the investigation of new strategies, or the screening of new types of doping. Nevertheless, due to the variability induced by indirect biomarkers, the consideration of confounding factors should continuously support this research. Beyond tremendous advances in analytical sensitivity, machine learning-based approaches seem inevitable to facilitate an expert interpretation of numerous biological profiles and promote anti-doping efforts. This perspective article highlights the current innovations of the Athlete Biological Passport that seem the most promising. Through different research axes, this short manuscript provides an opportunity to bring together approaches that are more widely exploited (e.g., omics strategies) and others in the early stages of investigation (e.g., artificial intelligence) seeking to develop the ABP. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666424/ /pubmed/36406774 http://dx.doi.org/10.3389/fspor.2022.986875 Text en Copyright © 2022 Krumm, Botrè, Saugy and Faiss. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Sports and Active Living
Krumm, Bastien
Botrè, Francesco
Saugy, Jonas J.
Faiss, Raphael
Future opportunities for the Athlete Biological Passport
title Future opportunities for the Athlete Biological Passport
title_full Future opportunities for the Athlete Biological Passport
title_fullStr Future opportunities for the Athlete Biological Passport
title_full_unstemmed Future opportunities for the Athlete Biological Passport
title_short Future opportunities for the Athlete Biological Passport
title_sort future opportunities for the athlete biological passport
topic Sports and Active Living
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666424/
https://www.ncbi.nlm.nih.gov/pubmed/36406774
http://dx.doi.org/10.3389/fspor.2022.986875
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