Cargando…

Identification of HLA class I-restricted immunogenic neoantigens in triple negative breast cancer

Immune checkpoint inhibitor (ICI)-based immunotherapy in triple negative breast cancer (TNBC) is achieving limited therapeutic results, requiring the development of more potent strategies. Combination of ICI with vaccination strategies would enhance antitumor immunity and response rates to ICI in pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aparicio, Belén, Repáraz, David, Ruiz, Marta, Llopiz, Diana, Silva, Leyre, Vercher, Enric, Theunissen, Patrick, Tamayo, Ibon, Smerdou, Cristian, Igea, Ana, Santisteban, Marta, Gónzalez-Deza, Cristina, Lasarte, Juan J., Hervás-Stubbs, Sandra, Sarobe, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666480/ https://www.ncbi.nlm.nih.gov/pubmed/36405725 http://dx.doi.org/10.3389/fimmu.2022.985886

Ejemplares similares

Therapeutic Vaccines against Hepatocellular Carcinoma in the Immune Checkpoint Inhibitor Era: Time for Neoantigens?
por: Repáraz, David, et al.
Publicado: (2022)

Neoantigens as potential vaccines in hepatocellular carcinoma
por: Repáraz, David, et al.
Publicado: (2022)

Gemcitabine-mediated depletion of immunosuppressive dendritic cells enhances the efficacy of therapeutic vaccination
por: Repáraz, David, et al.
Publicado: (2022)

Cold-Inducible RNA Binding Protein as a Vaccination Platform to Enhance Immunotherapeutic Responses against Hepatocellular Carcinoma
por: Silva, Leyre, et al.
Publicado: (2020)

IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination
por: Llopiz, Diana, et al.
Publicado: (2016)

Inflammation and immunity in ovarian cancer
por: Salas-Benito, Diego, et al.
Publicado: (2020)

Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor
por: Lozano, Teresa, et al.
Publicado: (2017)

Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10
por: Llopiz, Diana, et al.
Publicado: (2018)

Mutated trimeric RBD vaccines: a platform against variants of concern
por: Aparicio, Belén, et al.
Publicado: (2023)

Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy
por: Navarro, Flor, et al.
Publicado: (2022)

Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses
por: Aparicio, Belén, et al.
Publicado: (2021)

Erratum: Enhanced cross-recognition of SARS-CoV-2 Omicron variant by peptide vaccine-induced antibodies
por: Aparicio, Belén, et al.
Publicado: (2023)

Enhanced cross-recognition of SARS-CoV-2 Omicron variant by peptide vaccine-induced antibodies
por: Aparicio, Belén, et al.
Publicado: (2023)

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA
por: Chandran, Smita S., et al.
Publicado: (2022)

Helper cell-independent antitumor activity of potent CD8(+) T cell epitope peptide vaccines is dependent upon CD40L
por: Llopiz, Diana, et al.
Publicado: (2013)

Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice
por: Lasarte-Cia, Aritz, et al.
Publicado: (2018)

Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair–deficient colorectal cancer tissue
por: Hirama, Tomomi, et al.
Publicado: (2021)

Structure Based Prediction of Neoantigen Immunogenicity
por: Riley, Timothy P., et al.
Publicado: (2019)

Molecular mechanism of phosphopeptide neoantigen immunogenicity
por: Patskovsky, Yury, et al.
Publicado: (2023)

DeepHLApan: A Deep Learning Approach for Neoantigen Prediction Considering Both HLA-Peptide Binding and Immunogenicity
por: Wu, Jingcheng, et al.
Publicado: (2019)

Cancer neoantigens and immunogenicity: mutation position matters
por: Capietto, Aude-Hélène, et al.
Publicado: (2020)

Genetic Modification of CD8(+) T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies
por: Lozano, Teresa, et al.
Publicado: (2019)

Pre‐existing heterologous T‐cell immunity and neoantigen immunogenicity
por: Leng, Qibin, et al.
Publicado: (2020)

3348 Structural Determinants of Neoantigen Immunogenicity for Cancer Therapy
por: Devlin, Jason, et al.
Publicado: (2019)

DeepNeo: a webserver for predicting immunogenic neoantigens
por: Kim, Jeong Yeon, et al.
Publicado: (2023)

Author Correction: Molecular mechanism of phosphopeptide neoantigen immunogenicity
por: Patskovsky, Yury, et al.
Publicado: (2023)

Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models
por: Zhang, Rui, et al.
Publicado: (2019)

The immunological profile of tumor-bearing animals determines the outcome of cancer immunotherapy
por: Quetglas, José I, et al.
Publicado: (2013)

Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
por: Hwang, Michael S., et al.
Publicado: (2021)

Clinical testing of a dendritic cell targeted therapeutic vaccine in patients with chronic hepatitis C virus infection
por: Zabaleta, Aintzane, et al.
Publicado: (2015)

Advances in immunotherapy for hepatocellular carcinoma
por: Sangro, Bruno, et al.
Publicado: (2021)

Immunotherapy generates selective pressure for acquisition of immunogenic neoantigens in escape tumors
por: Pan, Jenny H, et al.
Publicado: (2015)

Immunogenic neoantigens derived from gene fusions stimulate T cell responses
por: Yang, Wei, et al.
Publicado: (2019)

Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis
por: Nibeyro, Guadalupe, et al.
Publicado: (2023)

Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes
por: Castro, Andrea, et al.
Publicado: (2019)

Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors
por: Wang, Wenwen, et al.
Publicado: (2022)

INeo-Epp: A Novel T-Cell HLA Class-I Immunogenicity or Neoantigenic Epitope Prediction Method Based on Sequence-Related Amino Acid Features
por: Wang, Guangzhi, et al.
Publicado: (2020)

Multi-step screening of neoantigens’ HLA- and TCR-interfaces improves prediction of survival
por: Richard, Guilhem, et al.
Publicado: (2021)

Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment
por: Newey, Alice, et al.
Publicado: (2019)

Seq2Neo: A Comprehensive Pipeline for Cancer Neoantigen Immunogenicity Prediction
por: Diao, Kaixuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mm4vg6g3p93v2q4k3fj7gpuibl