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Exploring the influence of takotsubo syndrome on oncologic patients’ mortality

It has been reported that patients affected by takotsubo syndrome (TTS) with a concurrent diagnosis of cancer suffer from greater mortality as compared to their non-cancer counterpart. It remains unclear whether TTS worsens the prognosis of cancer patients as well. Aim of this study was to compare o...

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Autores principales: Tini, Giacomo, Arcari, Luca, Sclafani, Matteo, Spallarossa, Paolo, Camastra, Giovanni, Battistoni, Allegra, Autore, Camillo, Volpe, Massimo, Musumeci, Beatrice, Ameri, Pietro, Cacciotti, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666486/
https://www.ncbi.nlm.nih.gov/pubmed/36407443
http://dx.doi.org/10.3389/fcvm.2022.1020078
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author Tini, Giacomo
Arcari, Luca
Sclafani, Matteo
Spallarossa, Paolo
Camastra, Giovanni
Battistoni, Allegra
Autore, Camillo
Volpe, Massimo
Musumeci, Beatrice
Ameri, Pietro
Cacciotti, Luca
author_facet Tini, Giacomo
Arcari, Luca
Sclafani, Matteo
Spallarossa, Paolo
Camastra, Giovanni
Battistoni, Allegra
Autore, Camillo
Volpe, Massimo
Musumeci, Beatrice
Ameri, Pietro
Cacciotti, Luca
author_sort Tini, Giacomo
collection PubMed
description It has been reported that patients affected by takotsubo syndrome (TTS) with a concurrent diagnosis of cancer suffer from greater mortality as compared to their non-cancer counterpart. It remains unclear whether TTS worsens the prognosis of cancer patients as well. Aim of this study was to compare outcomes of cancer patients with and without TTS. We combined data from two independent cohorts: one consisted of a prospective multicentre TTS registry; the second cohort consisted of all oncologic patients from two Cardio-Oncology Outpatient Clinics, who did not have cardiovascular conditions at the time of the cardio-oncologic visit. From the TTS registry, we selected patients with cancer (cancer-TTS patients). Next, we matched these patients with those from the cardio-oncologic cohort (cancer non-TTS patients) in a 1:2 fashion by age, sex, and type and cancer staging. Study endpoint was all-cause mortality. Among 318 TTS patients, 42 (13%) had a concurrent diagnosis of cancer. Characteristics of cancer-TTS patients and of the 84 matched cancer non-TTS subjects were comparable with the exception of diabetes mellitus, which was more common in cancer non-TTS patients. All-cause mortality was similar between cancer-TTS and cancer non-TTS patients. At Cox regression analysis TTS was not associated with mortality (OR 1.4, 95% CI 0.6–3.3, p = 0.43). Our findings show that even in the presence of acute heart failure due to TTS, the prognosis of oncologic patients is driven by the malignancy itself. Our results may prove useful for integrated management of cardio-oncologic patients.
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spelling pubmed-96664862022-11-17 Exploring the influence of takotsubo syndrome on oncologic patients’ mortality Tini, Giacomo Arcari, Luca Sclafani, Matteo Spallarossa, Paolo Camastra, Giovanni Battistoni, Allegra Autore, Camillo Volpe, Massimo Musumeci, Beatrice Ameri, Pietro Cacciotti, Luca Front Cardiovasc Med Cardiovascular Medicine It has been reported that patients affected by takotsubo syndrome (TTS) with a concurrent diagnosis of cancer suffer from greater mortality as compared to their non-cancer counterpart. It remains unclear whether TTS worsens the prognosis of cancer patients as well. Aim of this study was to compare outcomes of cancer patients with and without TTS. We combined data from two independent cohorts: one consisted of a prospective multicentre TTS registry; the second cohort consisted of all oncologic patients from two Cardio-Oncology Outpatient Clinics, who did not have cardiovascular conditions at the time of the cardio-oncologic visit. From the TTS registry, we selected patients with cancer (cancer-TTS patients). Next, we matched these patients with those from the cardio-oncologic cohort (cancer non-TTS patients) in a 1:2 fashion by age, sex, and type and cancer staging. Study endpoint was all-cause mortality. Among 318 TTS patients, 42 (13%) had a concurrent diagnosis of cancer. Characteristics of cancer-TTS patients and of the 84 matched cancer non-TTS subjects were comparable with the exception of diabetes mellitus, which was more common in cancer non-TTS patients. All-cause mortality was similar between cancer-TTS and cancer non-TTS patients. At Cox regression analysis TTS was not associated with mortality (OR 1.4, 95% CI 0.6–3.3, p = 0.43). Our findings show that even in the presence of acute heart failure due to TTS, the prognosis of oncologic patients is driven by the malignancy itself. Our results may prove useful for integrated management of cardio-oncologic patients. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666486/ /pubmed/36407443 http://dx.doi.org/10.3389/fcvm.2022.1020078 Text en Copyright © 2022 Tini, Arcari, Sclafani, Spallarossa, Camastra, Battistoni, Autore, Volpe, Musumeci, Ameri and Cacciotti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Tini, Giacomo
Arcari, Luca
Sclafani, Matteo
Spallarossa, Paolo
Camastra, Giovanni
Battistoni, Allegra
Autore, Camillo
Volpe, Massimo
Musumeci, Beatrice
Ameri, Pietro
Cacciotti, Luca
Exploring the influence of takotsubo syndrome on oncologic patients’ mortality
title Exploring the influence of takotsubo syndrome on oncologic patients’ mortality
title_full Exploring the influence of takotsubo syndrome on oncologic patients’ mortality
title_fullStr Exploring the influence of takotsubo syndrome on oncologic patients’ mortality
title_full_unstemmed Exploring the influence of takotsubo syndrome on oncologic patients’ mortality
title_short Exploring the influence of takotsubo syndrome on oncologic patients’ mortality
title_sort exploring the influence of takotsubo syndrome on oncologic patients’ mortality
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666486/
https://www.ncbi.nlm.nih.gov/pubmed/36407443
http://dx.doi.org/10.3389/fcvm.2022.1020078
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