Interruption of post-Golgi STING trafficking activates tonic interferon signaling

Activation of the cGAS-STING pathway is traditionally considered a “trigger-release” mechanism where detection of microbial DNA or cyclic di-nucleotides sets off the type I interferon response. Whether this pathway can be activated without pathogenic ligand exposure is less well understood. Here we...

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Detalles Bibliográficos
Autores principales: Tu, Xintao, Chu, Ting-Ting, Jeltema, Devon, Abbott, Kennady, Yang, Kun, Xing, Cong, Han, Jie, Dobbs, Nicole, Yan, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666523/
https://www.ncbi.nlm.nih.gov/pubmed/36379959
http://dx.doi.org/10.1038/s41467-022-33765-0

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