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Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics

The final steps of lagging strand synthesis induce maturation of Okazaki fragments via removal of the RNA primers and ligation. Iterative cycles between Polymerase δ (Polδ) and Flap endonuclease-1 (FEN1) remove the primer, with an intermediary nick structure generated for each cycle. Here, we show t...

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Detalles Bibliográficos
Autores principales:	Raducanu, Vlad-Stefan, Tehseen, Muhammad, Al-Amodi, Amani, Joudeh, Luay I., De Biasio, Alfredo, Hamdan, Samir M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666535/ https://www.ncbi.nlm.nih.gov/pubmed/36379932 http://dx.doi.org/10.1038/s41467-022-34751-2

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