Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics

Caspase-2 (Casp2) is a promising therapeutic target in several human diseases, including nonalcoholic steatohepatitis (NASH) and Alzheimer’s disease (AD). However, the design of an active-site-directed inhibitor selective to individual caspase family members is challenging because caspases have extr...

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Detalles Bibliográficos
Autores principales: Bosc, Elodie, Anastasie, Julie, Soualmia, Feryel, Coric, Pascale, Kim, Ju Youn, Wang, Lily Q., Lacin, Gullen, Zhao, Kaitao, Patel, Ronak, Duplus, Eric, Tixador, Philippe, Sproul, Andrew A., Brugg, Bernard, Reboud-Ravaux, Michelle, Troy, Carol M., Shelanski, Michael L., Bouaziz, Serge, Karin, Michael, El Amri, Chahrazade, Jacotot, Etienne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666555/
https://www.ncbi.nlm.nih.gov/pubmed/36379916
http://dx.doi.org/10.1038/s41419-022-05396-2

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