Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy

Alterations of serine/threonine phosphorylation of the cardiac proteome are a hallmark of heart failure. However, the contribution of tyrosine phosphorylation (pTyr) to the pathogenesis of cardiac hypertrophy remains unclear. We use global mapping to discover and quantify site-specific pTyr in two c...

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Detalles Bibliográficos
Autores principales: Xu, Mingguo, Bermea, Kevin C., Ayati, Marzieh, Kim, Han Byeol, Yang, Xiaomei, Medina, Andres, Fu, Zongming, Heravi, Amir, Zhang, Xinyu, Na, Chan Hyun, Everett, Allen D., Gabrielson, Kathleen, Foster, D. Brian, Paolocci, Nazareno, Murphy, Anne M., Ramirez-Correa, Genaro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666710/
https://www.ncbi.nlm.nih.gov/pubmed/36380187
http://dx.doi.org/10.1038/s42003-022-04021-4

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