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Functional and clinical characteristics of focal adhesion kinases in cancer progression
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tum...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666724/ https://www.ncbi.nlm.nih.gov/pubmed/36407100 http://dx.doi.org/10.3389/fcell.2022.1040311 |
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author | Zhang, Zhaoyu Li, Jinlong Jiao, Simin Han, Guangda Zhu, Jiaming Liu, Tianzhou |
author_facet | Zhang, Zhaoyu Li, Jinlong Jiao, Simin Han, Guangda Zhu, Jiaming Liu, Tianzhou |
author_sort | Zhang, Zhaoyu |
collection | PubMed |
description | Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis. At the molecular level, FAK promotes tumor progression mainly by altering survival signals, invasive capacity, epithelial-mesenchymal transition, the tumor microenvironment, the Warburg effect, and stemness of tumor cells. Many effective drugs have been developed based on the comprehensive role of FAK in tumor cells. In addition, its potential as a tumor marker cannot be ignored. Here, we discuss the pathological and pre-clinical evidence of the role of FAK in cancer development; we hope that these findings will assist in FAK-based clinical studies. |
format | Online Article Text |
id | pubmed-9666724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96667242022-11-17 Functional and clinical characteristics of focal adhesion kinases in cancer progression Zhang, Zhaoyu Li, Jinlong Jiao, Simin Han, Guangda Zhu, Jiaming Liu, Tianzhou Front Cell Dev Biol Cell and Developmental Biology Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis. At the molecular level, FAK promotes tumor progression mainly by altering survival signals, invasive capacity, epithelial-mesenchymal transition, the tumor microenvironment, the Warburg effect, and stemness of tumor cells. Many effective drugs have been developed based on the comprehensive role of FAK in tumor cells. In addition, its potential as a tumor marker cannot be ignored. Here, we discuss the pathological and pre-clinical evidence of the role of FAK in cancer development; we hope that these findings will assist in FAK-based clinical studies. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666724/ /pubmed/36407100 http://dx.doi.org/10.3389/fcell.2022.1040311 Text en Copyright © 2022 Zhang, Li, Jiao, Han, Zhu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhang, Zhaoyu Li, Jinlong Jiao, Simin Han, Guangda Zhu, Jiaming Liu, Tianzhou Functional and clinical characteristics of focal adhesion kinases in cancer progression |
title | Functional and clinical characteristics of focal adhesion kinases in cancer progression |
title_full | Functional and clinical characteristics of focal adhesion kinases in cancer progression |
title_fullStr | Functional and clinical characteristics of focal adhesion kinases in cancer progression |
title_full_unstemmed | Functional and clinical characteristics of focal adhesion kinases in cancer progression |
title_short | Functional and clinical characteristics of focal adhesion kinases in cancer progression |
title_sort | functional and clinical characteristics of focal adhesion kinases in cancer progression |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666724/ https://www.ncbi.nlm.nih.gov/pubmed/36407100 http://dx.doi.org/10.3389/fcell.2022.1040311 |
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