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Functional and clinical characteristics of focal adhesion kinases in cancer progression

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tum...

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Autores principales: Zhang, Zhaoyu, Li, Jinlong, Jiao, Simin, Han, Guangda, Zhu, Jiaming, Liu, Tianzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666724/
https://www.ncbi.nlm.nih.gov/pubmed/36407100
http://dx.doi.org/10.3389/fcell.2022.1040311
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author Zhang, Zhaoyu
Li, Jinlong
Jiao, Simin
Han, Guangda
Zhu, Jiaming
Liu, Tianzhou
author_facet Zhang, Zhaoyu
Li, Jinlong
Jiao, Simin
Han, Guangda
Zhu, Jiaming
Liu, Tianzhou
author_sort Zhang, Zhaoyu
collection PubMed
description Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis. At the molecular level, FAK promotes tumor progression mainly by altering survival signals, invasive capacity, epithelial-mesenchymal transition, the tumor microenvironment, the Warburg effect, and stemness of tumor cells. Many effective drugs have been developed based on the comprehensive role of FAK in tumor cells. In addition, its potential as a tumor marker cannot be ignored. Here, we discuss the pathological and pre-clinical evidence of the role of FAK in cancer development; we hope that these findings will assist in FAK-based clinical studies.
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spelling pubmed-96667242022-11-17 Functional and clinical characteristics of focal adhesion kinases in cancer progression Zhang, Zhaoyu Li, Jinlong Jiao, Simin Han, Guangda Zhu, Jiaming Liu, Tianzhou Front Cell Dev Biol Cell and Developmental Biology Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in response to stress. Increasing evidence has shown that at the pathological level, FAK is highly expressed in multiple tumors in several systems (including lung, liver, gastric, and colorectal cancers) and correlates with tumor aggressiveness and patient prognosis. At the molecular level, FAK promotes tumor progression mainly by altering survival signals, invasive capacity, epithelial-mesenchymal transition, the tumor microenvironment, the Warburg effect, and stemness of tumor cells. Many effective drugs have been developed based on the comprehensive role of FAK in tumor cells. In addition, its potential as a tumor marker cannot be ignored. Here, we discuss the pathological and pre-clinical evidence of the role of FAK in cancer development; we hope that these findings will assist in FAK-based clinical studies. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666724/ /pubmed/36407100 http://dx.doi.org/10.3389/fcell.2022.1040311 Text en Copyright © 2022 Zhang, Li, Jiao, Han, Zhu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhang, Zhaoyu
Li, Jinlong
Jiao, Simin
Han, Guangda
Zhu, Jiaming
Liu, Tianzhou
Functional and clinical characteristics of focal adhesion kinases in cancer progression
title Functional and clinical characteristics of focal adhesion kinases in cancer progression
title_full Functional and clinical characteristics of focal adhesion kinases in cancer progression
title_fullStr Functional and clinical characteristics of focal adhesion kinases in cancer progression
title_full_unstemmed Functional and clinical characteristics of focal adhesion kinases in cancer progression
title_short Functional and clinical characteristics of focal adhesion kinases in cancer progression
title_sort functional and clinical characteristics of focal adhesion kinases in cancer progression
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666724/
https://www.ncbi.nlm.nih.gov/pubmed/36407100
http://dx.doi.org/10.3389/fcell.2022.1040311
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