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Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report

Lung adenocarcinoma, the most common subtype of lung cancer, has been always imposed serious threat to human health. Congenital pulmonary dysplasia (CPD) lacking typical clinical manifestations is a rare developmental anomaly. Pulmonary aplasia, the rarest subtype of CPD, may present with a variety...

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Autores principales: Min, Bo, Wang, Chu-xu, Liu, Juan, Gong, Li, Wang, Cheng-xiang, Zuo, Xiao-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666727/
https://www.ncbi.nlm.nih.gov/pubmed/36408132
http://dx.doi.org/10.3389/fonc.2022.959502
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author Min, Bo
Wang, Chu-xu
Liu, Juan
Gong, Li
Wang, Cheng-xiang
Zuo, Xiao-hua
author_facet Min, Bo
Wang, Chu-xu
Liu, Juan
Gong, Li
Wang, Cheng-xiang
Zuo, Xiao-hua
author_sort Min, Bo
collection PubMed
description Lung adenocarcinoma, the most common subtype of lung cancer, has been always imposed serious threat to human health. Congenital pulmonary dysplasia (CPD) lacking typical clinical manifestations is a rare developmental anomaly. Pulmonary aplasia, the rarest subtype of CPD, may present with a variety of symptoms and is frequently associated with other abnormalities. This report describes an 81-year-old woman who presented with an irritant cough. Chest computed tomography (CT) and three-dimensional (3D) reconstruction revealed an irregular mass with a diameter of 5 cm in right lower lobe adjacent to the hilum. CT also indicated a rightward mediastinal shift and the complete absence of ipsilateral upper lobar tissue with bronchus ending in a terminal cecum, resulting in a diagnosis of pulmonary aplasia. The patient accepted lobectomy and lymph node dissection without complication, histopathologic examination combined HE staining with immunohistochemistry identified the tumor as adenocarcinoma. Three months after surgery, the patient was free of respiratory symptoms without chest pain. This report highlights the necessity of comprehensive evaluation for lung malignancy concurrent with CPD and the importance of identifying the diagnosis of pulmonary dysplasia.
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spelling pubmed-96667272022-11-17 Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report Min, Bo Wang, Chu-xu Liu, Juan Gong, Li Wang, Cheng-xiang Zuo, Xiao-hua Front Oncol Oncology Lung adenocarcinoma, the most common subtype of lung cancer, has been always imposed serious threat to human health. Congenital pulmonary dysplasia (CPD) lacking typical clinical manifestations is a rare developmental anomaly. Pulmonary aplasia, the rarest subtype of CPD, may present with a variety of symptoms and is frequently associated with other abnormalities. This report describes an 81-year-old woman who presented with an irritant cough. Chest computed tomography (CT) and three-dimensional (3D) reconstruction revealed an irregular mass with a diameter of 5 cm in right lower lobe adjacent to the hilum. CT also indicated a rightward mediastinal shift and the complete absence of ipsilateral upper lobar tissue with bronchus ending in a terminal cecum, resulting in a diagnosis of pulmonary aplasia. The patient accepted lobectomy and lymph node dissection without complication, histopathologic examination combined HE staining with immunohistochemistry identified the tumor as adenocarcinoma. Three months after surgery, the patient was free of respiratory symptoms without chest pain. This report highlights the necessity of comprehensive evaluation for lung malignancy concurrent with CPD and the importance of identifying the diagnosis of pulmonary dysplasia. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666727/ /pubmed/36408132 http://dx.doi.org/10.3389/fonc.2022.959502 Text en Copyright © 2022 Min, Wang, Liu, Gong, Wang and Zuo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Min, Bo
Wang, Chu-xu
Liu, Juan
Gong, Li
Wang, Cheng-xiang
Zuo, Xiao-hua
Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
title Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
title_full Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
title_fullStr Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
title_full_unstemmed Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
title_short Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
title_sort lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666727/
https://www.ncbi.nlm.nih.gov/pubmed/36408132
http://dx.doi.org/10.3389/fonc.2022.959502
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