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Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666758/ https://www.ncbi.nlm.nih.gov/pubmed/36408261 http://dx.doi.org/10.3389/fphar.2022.986436 |
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author | Wei, Qian Hao, Xia Lau, Benson Wui-Man Wang, Shaoxia Li, Yue |
author_facet | Wei, Qian Hao, Xia Lau, Benson Wui-Man Wang, Shaoxia Li, Yue |
author_sort | Wei, Qian |
collection | PubMed |
description | It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharmacological effects and is beneficial in enhancing osteogenic differentiation and cardiovascular disease. Baicalin’s profound metabolic impact on various stem cell populations and their fate specification could improve the efficiency of stem cell therapy for climacteric syndrome. However, Baicalin-mediated processes are complex and many of the underlying mechanisms are not fully fathomed yet. This review aims to shed light on the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and provide a good cell source for stem cell therapy to broaden the therapeutic landscape for climacteric syndrome patients. |
format | Online Article Text |
id | pubmed-9666758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96667582022-11-17 Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome Wei, Qian Hao, Xia Lau, Benson Wui-Man Wang, Shaoxia Li, Yue Front Pharmacol Pharmacology It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharmacological effects and is beneficial in enhancing osteogenic differentiation and cardiovascular disease. Baicalin’s profound metabolic impact on various stem cell populations and their fate specification could improve the efficiency of stem cell therapy for climacteric syndrome. However, Baicalin-mediated processes are complex and many of the underlying mechanisms are not fully fathomed yet. This review aims to shed light on the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and provide a good cell source for stem cell therapy to broaden the therapeutic landscape for climacteric syndrome patients. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666758/ /pubmed/36408261 http://dx.doi.org/10.3389/fphar.2022.986436 Text en Copyright © 2022 Wei, Hao, Lau, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Wei, Qian Hao, Xia Lau, Benson Wui-Man Wang, Shaoxia Li, Yue Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome |
title | Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome |
title_full | Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome |
title_fullStr | Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome |
title_full_unstemmed | Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome |
title_short | Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome |
title_sort | baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666758/ https://www.ncbi.nlm.nih.gov/pubmed/36408261 http://dx.doi.org/10.3389/fphar.2022.986436 |
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