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Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome

It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharm...

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Autores principales: Wei, Qian, Hao, Xia, Lau, Benson Wui-Man, Wang, Shaoxia, Li, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666758/
https://www.ncbi.nlm.nih.gov/pubmed/36408261
http://dx.doi.org/10.3389/fphar.2022.986436
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author Wei, Qian
Hao, Xia
Lau, Benson Wui-Man
Wang, Shaoxia
Li, Yue
author_facet Wei, Qian
Hao, Xia
Lau, Benson Wui-Man
Wang, Shaoxia
Li, Yue
author_sort Wei, Qian
collection PubMed
description It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharmacological effects and is beneficial in enhancing osteogenic differentiation and cardiovascular disease. Baicalin’s profound metabolic impact on various stem cell populations and their fate specification could improve the efficiency of stem cell therapy for climacteric syndrome. However, Baicalin-mediated processes are complex and many of the underlying mechanisms are not fully fathomed yet. This review aims to shed light on the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and provide a good cell source for stem cell therapy to broaden the therapeutic landscape for climacteric syndrome patients.
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spelling pubmed-96667582022-11-17 Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome Wei, Qian Hao, Xia Lau, Benson Wui-Man Wang, Shaoxia Li, Yue Front Pharmacol Pharmacology It is widely acknowledged that the climacteric syndrome negatively affects women’s quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharmacological effects and is beneficial in enhancing osteogenic differentiation and cardiovascular disease. Baicalin’s profound metabolic impact on various stem cell populations and their fate specification could improve the efficiency of stem cell therapy for climacteric syndrome. However, Baicalin-mediated processes are complex and many of the underlying mechanisms are not fully fathomed yet. This review aims to shed light on the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and provide a good cell source for stem cell therapy to broaden the therapeutic landscape for climacteric syndrome patients. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9666758/ /pubmed/36408261 http://dx.doi.org/10.3389/fphar.2022.986436 Text en Copyright © 2022 Wei, Hao, Lau, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wei, Qian
Hao, Xia
Lau, Benson Wui-Man
Wang, Shaoxia
Li, Yue
Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
title Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
title_full Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
title_fullStr Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
title_full_unstemmed Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
title_short Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
title_sort baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666758/
https://www.ncbi.nlm.nih.gov/pubmed/36408261
http://dx.doi.org/10.3389/fphar.2022.986436
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