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Presepsin levels and COVID-19 severity: a systematic review and meta-analysis
Plasmatic presepsin (PSP) is a novel biomarker reported to be useful for sepsis diagnosis and prognosis. During the pandemic, only few studies highlighted a possible correlation between PSP and COVID-19 severity, but results remain inconsistent. The present study aims to establish the correlation be...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666937/ https://www.ncbi.nlm.nih.gov/pubmed/36380007 http://dx.doi.org/10.1007/s10238-022-00936-8 |
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author | Guarino, Matteo Perna, Benedetta Maritati, Martina Remelli, Francesca Trevisan, Caterina Spampinato, Michele Domenico Costanzini, Anna Volpato, Stefano Contini, Carlo De Giorgio, Roberto |
author_facet | Guarino, Matteo Perna, Benedetta Maritati, Martina Remelli, Francesca Trevisan, Caterina Spampinato, Michele Domenico Costanzini, Anna Volpato, Stefano Contini, Carlo De Giorgio, Roberto |
author_sort | Guarino, Matteo |
collection | PubMed |
description | Plasmatic presepsin (PSP) is a novel biomarker reported to be useful for sepsis diagnosis and prognosis. During the pandemic, only few studies highlighted a possible correlation between PSP and COVID-19 severity, but results remain inconsistent. The present study aims to establish the correlation between PSP and COVID-19 severity. English-language papers assessing a correlation between COVID-19 and PSP from MEDLINE, PubMed, Google Scholar, Cochrane Library, MeSH, LitCovid NLM, EMBASE, CINAHL Plus and the World Health Organization (WHO) website, published from January 2020 were considered with no publication date limitations. Two independent reviewers performed data abstraction and quality assessment, and one reviewer resolved inconsistencies. The protocol was registered on PROSPERO (CRD42022325971).Fifteen articles met our eligibility criteria. The aggregate study population included 1373 COVID-19 patients who had undergone a PSP assessment. The random-effect meta-analysis was performed in 7 out of 15 selected studies, considering only those reporting the mean PSP levels in low- and high-severity cases (n = 707).The results showed that the pooled mean difference of PSP levels between high- and low-severity COVID-19 patients was 441.70 pg/ml (95%CI: 150.40–732.99 pg/ml).Our data show that presepsin is a promising biomarker that can express COVID-19 severity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10238-022-00936-8. |
format | Online Article Text |
id | pubmed-9666937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-96669372022-11-16 Presepsin levels and COVID-19 severity: a systematic review and meta-analysis Guarino, Matteo Perna, Benedetta Maritati, Martina Remelli, Francesca Trevisan, Caterina Spampinato, Michele Domenico Costanzini, Anna Volpato, Stefano Contini, Carlo De Giorgio, Roberto Clin Exp Med Review Article Plasmatic presepsin (PSP) is a novel biomarker reported to be useful for sepsis diagnosis and prognosis. During the pandemic, only few studies highlighted a possible correlation between PSP and COVID-19 severity, but results remain inconsistent. The present study aims to establish the correlation between PSP and COVID-19 severity. English-language papers assessing a correlation between COVID-19 and PSP from MEDLINE, PubMed, Google Scholar, Cochrane Library, MeSH, LitCovid NLM, EMBASE, CINAHL Plus and the World Health Organization (WHO) website, published from January 2020 were considered with no publication date limitations. Two independent reviewers performed data abstraction and quality assessment, and one reviewer resolved inconsistencies. The protocol was registered on PROSPERO (CRD42022325971).Fifteen articles met our eligibility criteria. The aggregate study population included 1373 COVID-19 patients who had undergone a PSP assessment. The random-effect meta-analysis was performed in 7 out of 15 selected studies, considering only those reporting the mean PSP levels in low- and high-severity cases (n = 707).The results showed that the pooled mean difference of PSP levels between high- and low-severity COVID-19 patients was 441.70 pg/ml (95%CI: 150.40–732.99 pg/ml).Our data show that presepsin is a promising biomarker that can express COVID-19 severity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10238-022-00936-8. Springer International Publishing 2022-11-15 2023 /pmc/articles/PMC9666937/ /pubmed/36380007 http://dx.doi.org/10.1007/s10238-022-00936-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Guarino, Matteo Perna, Benedetta Maritati, Martina Remelli, Francesca Trevisan, Caterina Spampinato, Michele Domenico Costanzini, Anna Volpato, Stefano Contini, Carlo De Giorgio, Roberto Presepsin levels and COVID-19 severity: a systematic review and meta-analysis |
title | Presepsin levels and COVID-19 severity: a systematic review and meta-analysis |
title_full | Presepsin levels and COVID-19 severity: a systematic review and meta-analysis |
title_fullStr | Presepsin levels and COVID-19 severity: a systematic review and meta-analysis |
title_full_unstemmed | Presepsin levels and COVID-19 severity: a systematic review and meta-analysis |
title_short | Presepsin levels and COVID-19 severity: a systematic review and meta-analysis |
title_sort | presepsin levels and covid-19 severity: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666937/ https://www.ncbi.nlm.nih.gov/pubmed/36380007 http://dx.doi.org/10.1007/s10238-022-00936-8 |
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