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Association between glucosamine use and cancer mortality: A large prospective cohort study

OBJECTIVE: Previous studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers based on the UK Biobank cohort study. MATERIALS AND METHODS:...

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Autores principales: Zhou, Jian, Wu, Ziyi, Lin, Zhengjun, Wang, Wanchun, Wan, Rongjun, Liu, Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667031/
https://www.ncbi.nlm.nih.gov/pubmed/36407521
http://dx.doi.org/10.3389/fnut.2022.947818
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author Zhou, Jian
Wu, Ziyi
Lin, Zhengjun
Wang, Wanchun
Wan, Rongjun
Liu, Tang
author_facet Zhou, Jian
Wu, Ziyi
Lin, Zhengjun
Wang, Wanchun
Wan, Rongjun
Liu, Tang
author_sort Zhou, Jian
collection PubMed
description OBJECTIVE: Previous studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers based on the UK Biobank cohort study. MATERIALS AND METHODS: A total of 453,645 participants aged 38–73 who had no cancer at baseline were recruited between 2006 and 2010 and followed until March 2021. We used cox and poission proportional hazards models to explore the association between habitual use of glucosamine and cancer mortality. Subgroup analyses were conducted to understand the potential effect modifications of demographics, lifestyle factors, and health outcomes. Sensitivity analyses were performed to determine the robustness of the results. RESULTS: Of the participants, 88,224 (19.4%) reported habitual glucosamine use at baseline. There were 9,366 cancer deaths during a median follow-up of 12.1 years, and we observed a significant association between the use of glucosamine and lower overall cancer mortality (HR = 0.95, 95% CI = 0.90–1.00, p < 0.05), kidney cancer (IRR = 0.68, 95% CI = 0.49–0.95, p < 0.05), lung cancer mortality (IRR = 0.84, 95% CI = 0.74–0.95, p < 0.05), and rectum cancer (IRR = 0.76, 95% CI = 0.59–0.98, p < 0.05). Subgroup analysis showed that habitual glucosamine supplementation was correlated with lower overall cancer mortality among participants who were aged ≥ 60 years, male, current smoker, without high cholesterol and not obese. Sensitivity analysis showed that the results were stable. CONCLUSION: Habitual glucosamine use was significantly related to decreased overall cancer, kidney cancer, lung cancer, and rectum cancer mortality, based on data from the large-scale, nationwide, prospective UK Biobank cohort study.
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spelling pubmed-96670312022-11-17 Association between glucosamine use and cancer mortality: A large prospective cohort study Zhou, Jian Wu, Ziyi Lin, Zhengjun Wang, Wanchun Wan, Rongjun Liu, Tang Front Nutr Nutrition OBJECTIVE: Previous studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers based on the UK Biobank cohort study. MATERIALS AND METHODS: A total of 453,645 participants aged 38–73 who had no cancer at baseline were recruited between 2006 and 2010 and followed until March 2021. We used cox and poission proportional hazards models to explore the association between habitual use of glucosamine and cancer mortality. Subgroup analyses were conducted to understand the potential effect modifications of demographics, lifestyle factors, and health outcomes. Sensitivity analyses were performed to determine the robustness of the results. RESULTS: Of the participants, 88,224 (19.4%) reported habitual glucosamine use at baseline. There were 9,366 cancer deaths during a median follow-up of 12.1 years, and we observed a significant association between the use of glucosamine and lower overall cancer mortality (HR = 0.95, 95% CI = 0.90–1.00, p < 0.05), kidney cancer (IRR = 0.68, 95% CI = 0.49–0.95, p < 0.05), lung cancer mortality (IRR = 0.84, 95% CI = 0.74–0.95, p < 0.05), and rectum cancer (IRR = 0.76, 95% CI = 0.59–0.98, p < 0.05). Subgroup analysis showed that habitual glucosamine supplementation was correlated with lower overall cancer mortality among participants who were aged ≥ 60 years, male, current smoker, without high cholesterol and not obese. Sensitivity analysis showed that the results were stable. CONCLUSION: Habitual glucosamine use was significantly related to decreased overall cancer, kidney cancer, lung cancer, and rectum cancer mortality, based on data from the large-scale, nationwide, prospective UK Biobank cohort study. Frontiers Media S.A. 2022-11-02 /pmc/articles/PMC9667031/ /pubmed/36407521 http://dx.doi.org/10.3389/fnut.2022.947818 Text en Copyright © 2022 Zhou, Wu, Lin, Wang, Wan and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zhou, Jian
Wu, Ziyi
Lin, Zhengjun
Wang, Wanchun
Wan, Rongjun
Liu, Tang
Association between glucosamine use and cancer mortality: A large prospective cohort study
title Association between glucosamine use and cancer mortality: A large prospective cohort study
title_full Association between glucosamine use and cancer mortality: A large prospective cohort study
title_fullStr Association between glucosamine use and cancer mortality: A large prospective cohort study
title_full_unstemmed Association between glucosamine use and cancer mortality: A large prospective cohort study
title_short Association between glucosamine use and cancer mortality: A large prospective cohort study
title_sort association between glucosamine use and cancer mortality: a large prospective cohort study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667031/
https://www.ncbi.nlm.nih.gov/pubmed/36407521
http://dx.doi.org/10.3389/fnut.2022.947818
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