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Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?

PURPOSE: Heterozygous mutations in CTLA4 lead to an inborn error of immunity characterized by immune dysregulation and immunodeficiency, known as CTLA-4 insufficiency. Cohort studies on CTLA4 mutation carriers showed a reduced penetrance (around 70%) and variable disease expressivity, suggesting the...

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Detalles Bibliográficos
Autores principales:	Krausz, Máté, Mitsuiki, Noriko, Falcone, Valeria, Komp, Johanna, Posadas-Cantera, Sara, Lorenz, Hanns-Martin, Litzman, Jiri, Wolff, Daniel, Kanariou, Maria, Heinkele, Anita, Speckmann, Carsten, Häcker, Georg, Hengel, Hartmut, Gámez-Díaz, Laura, Grimbacher, Bodo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667032/ https://www.ncbi.nlm.nih.gov/pubmed/36405723 http://dx.doi.org/10.3389/fimmu.2022.1011646

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