Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia

Leishmania parasites harbor a unique network of circular DNA known as kinetoplast DNA (kDNA). The role of kDNA in leishmania infections is poorly understood. Herein, we show that kDNA delivery to the cytosol of Leishmania major infected THP-1 macrophages provoked increased parasite loads when compar...

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Detalles Bibliográficos
Autores principales: Yilmaz, Ismail Cem, Dunuroglu, Emre, Ayanoglu, Ihsan Cihan, Ipekoglu, Emre Mert, Yildirim, Muzaffer, Girginkardesler, Nogay, Ozbel, Yusuf, Toz, Seray, Ozbilgin, Ahmet, Aykut, Gamze, Gursel, Ihsan, Gursel, Mayda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667060/
https://www.ncbi.nlm.nih.gov/pubmed/36405710
http://dx.doi.org/10.3389/fimmu.2022.1007070

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