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Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy

BACKGROUND: The E2F family of transcription factors play a crucial role in the development of various cancers. However, E2F members lack targetable binding pockets and are typically considered “undruggable”. Unlike canonical small-molecule therapeutics, molecular glues mediate new E3 ligase–protein...

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Detalles Bibliográficos
Autores principales:	Liu, Ting-Ting, Yang, Heng, Zhuo, Fang-Fang, Yang, Zhuo, Zhao, Mei-Mei, Guo, Qiang, Liu, Yang, Liu, Dan, Zeng, Ke-Wu, Tu, Peng-Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667253/ https://www.ncbi.nlm.nih.gov/pubmed/36375317 http://dx.doi.org/10.1016/j.ebiom.2022.104353

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