Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition

Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor superfamily of proteins, is unique among serine protease inhibitors for exhibiting a spontaneous conformational change to a latent or inactive state. The functional half-life for this transition at physiologic tempe...

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Detalles Bibliográficos
Autores principales: Haynes, Laura M., Huttinger, Zachary M., Yee, Andrew, Kretz, Colin A., Siemieniak, David R., Lawrence, Daniel A., Ginsburg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667310/
https://www.ncbi.nlm.nih.gov/pubmed/36257408
http://dx.doi.org/10.1016/j.jbc.2022.102608

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