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Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities

Iris lactea Pall. var. chinensis (Fisch.) Koidz (Iris lactea) is an herbaceous perennial widely distributed in China, India, and South Korea. Iris lactea has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known...

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Autores principales: Tie, Fang-Fang, Fu, Yang-Yang, Hu, Na, Chen, Zhi, Wang, Hong-Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667474/
https://www.ncbi.nlm.nih.gov/pubmed/36425180
http://dx.doi.org/10.1039/d2ra05176a
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author Tie, Fang-Fang
Fu, Yang-Yang
Hu, Na
Chen, Zhi
Wang, Hong-Lun
author_facet Tie, Fang-Fang
Fu, Yang-Yang
Hu, Na
Chen, Zhi
Wang, Hong-Lun
author_sort Tie, Fang-Fang
collection PubMed
description Iris lactea Pall. var. chinensis (Fisch.) Koidz (Iris lactea) is an herbaceous perennial widely distributed in China, India, and South Korea. Iris lactea has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known oligostilbenes (compounds 2, 3 and 4) from the seeds of Iris lactea. The structures of these compounds were elucidated by HRESIMS, NMR, and chemical analyses. The network-based pharmacologic analysis platform was used to predict the target proteins related to inflammation of isolated compounds. Furthermore, the isolated compounds were tested for their anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. In this network, 138 candidate targets of compounds related to its therapeutic effect on inflammation were identified. In addition, compounds 1, 2, 3 and 4 significantly decreased NO content and the IL-6 levels as well as the expression of COX-2 in LPS-stimulated RAW 264.7 cells.
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spelling pubmed-96674742022-11-23 Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities Tie, Fang-Fang Fu, Yang-Yang Hu, Na Chen, Zhi Wang, Hong-Lun RSC Adv Chemistry Iris lactea Pall. var. chinensis (Fisch.) Koidz (Iris lactea) is an herbaceous perennial widely distributed in China, India, and South Korea. Iris lactea has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known oligostilbenes (compounds 2, 3 and 4) from the seeds of Iris lactea. The structures of these compounds were elucidated by HRESIMS, NMR, and chemical analyses. The network-based pharmacologic analysis platform was used to predict the target proteins related to inflammation of isolated compounds. Furthermore, the isolated compounds were tested for their anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. In this network, 138 candidate targets of compounds related to its therapeutic effect on inflammation were identified. In addition, compounds 1, 2, 3 and 4 significantly decreased NO content and the IL-6 levels as well as the expression of COX-2 in LPS-stimulated RAW 264.7 cells. The Royal Society of Chemistry 2022-11-16 /pmc/articles/PMC9667474/ /pubmed/36425180 http://dx.doi.org/10.1039/d2ra05176a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tie, Fang-Fang
Fu, Yang-Yang
Hu, Na
Chen, Zhi
Wang, Hong-Lun
Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities
title Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities
title_full Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities
title_fullStr Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities
title_full_unstemmed Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities
title_short Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities
title_sort isolation of oligostilbenes from iris lactea pall. var. chinensis (fisch.) koidz and their anti-inflammatory activities
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667474/
https://www.ncbi.nlm.nih.gov/pubmed/36425180
http://dx.doi.org/10.1039/d2ra05176a
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