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Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C

[Image: see text] The tumor suppressor protein p53 is inactivated in the majority of human cancers and remains a prime target for developing new drugs to reactivate its tumor suppressing activity for anticancer therapies. The oncogenic p53 mutant Y220C accounts for approximately 125,000 new cancer c...

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Detalles Bibliográficos
Autores principales:	Stephenson Clarke, Joseph R., Douglas, Leon R., Duriez, Patrick J., Balourdas, Dimitrios-Ilias, Joerger, Andreas C., Khadiullina, Raniya, Bulatov, Emil, Baud, Matthias G. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667543/ https://www.ncbi.nlm.nih.gov/pubmed/36407959 http://dx.doi.org/10.1021/acsptsci.2c00164

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