The role of neutrophil extracellular traps in cancer progression, metastasis and therapy

Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign pathogens and are strongly associated with autoimmune diseases. However, a novel and predo...

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Autores principales: Chen, Yue, Hu, Haoyue, Tan, Songtao, Dong, Qionglan, Fan, Xue, Wang, Yi, Zhang, Huan, He, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667637/
https://www.ncbi.nlm.nih.gov/pubmed/36384979
http://dx.doi.org/10.1186/s40164-022-00345-3
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author Chen, Yue
Hu, Haoyue
Tan, Songtao
Dong, Qionglan
Fan, Xue
Wang, Yi
Zhang, Huan
He, Jun
author_facet Chen, Yue
Hu, Haoyue
Tan, Songtao
Dong, Qionglan
Fan, Xue
Wang, Yi
Zhang, Huan
He, Jun
author_sort Chen, Yue
collection PubMed
description Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign pathogens and are strongly associated with autoimmune diseases. However, a novel and predominant role of NETs in cancer is emerging. Increasing evidence has confirmed that many stimuli can facilitate NET formation in an NADPH oxidase (NOX)-dependent/NOX-independent manner. In cancer, NETs have been linked to cancer progression, metastasis, and cancer-associated thrombosis. In this review, we aimed to summarize the current available knowledge regarding NET formation and focused on the role of NETs in cancer biological behaviors. The potential target for cancer therapy will be further discussed.
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spelling pubmed-96676372022-11-17 The role of neutrophil extracellular traps in cancer progression, metastasis and therapy Chen, Yue Hu, Haoyue Tan, Songtao Dong, Qionglan Fan, Xue Wang, Yi Zhang, Huan He, Jun Exp Hematol Oncol Review Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign pathogens and are strongly associated with autoimmune diseases. However, a novel and predominant role of NETs in cancer is emerging. Increasing evidence has confirmed that many stimuli can facilitate NET formation in an NADPH oxidase (NOX)-dependent/NOX-independent manner. In cancer, NETs have been linked to cancer progression, metastasis, and cancer-associated thrombosis. In this review, we aimed to summarize the current available knowledge regarding NET formation and focused on the role of NETs in cancer biological behaviors. The potential target for cancer therapy will be further discussed. BioMed Central 2022-11-16 /pmc/articles/PMC9667637/ /pubmed/36384979 http://dx.doi.org/10.1186/s40164-022-00345-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Yue
Hu, Haoyue
Tan, Songtao
Dong, Qionglan
Fan, Xue
Wang, Yi
Zhang, Huan
He, Jun
The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
title The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
title_full The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
title_fullStr The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
title_full_unstemmed The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
title_short The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
title_sort role of neutrophil extracellular traps in cancer progression, metastasis and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667637/
https://www.ncbi.nlm.nih.gov/pubmed/36384979
http://dx.doi.org/10.1186/s40164-022-00345-3
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